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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Early study, detailed description of findings, non-standard test animal

Data source

Reference
Reference Type:
publication
Title:
Experimentelle Studien ueber den Einfluß technisch und hygienisch wichtiger Gase und Daempfe auf den Organismus. Teil XII: Studien ueber Phosphortrichlorid
Author:
Butjagin PW
Year:
1904
Bibliographic source:
Arch Hygiene 49, 307-335

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Acute inhlation toxicity in cats; various expousre concentrations and times
GLP compliance:
no
Remarks:
: study pre-dates GLP
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Phosphorus trichloride
EC Number:
231-749-3
EC Name:
Phosphorus trichloride
Cas Number:
7719-12-2
Molecular formula:
Cl3P
IUPAC Name:
lambda6-phosphorus(3+) trichloride
Details on test material:
Phosphorus trichloride

Test animals

Species:
cat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
whole body
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
>= 3 - <= 10 h
Remarks on duration:
various exposure periods were used
Concentrations:
4-30, 40-330, 370-3870 ppm
(equivalent to 22.8-171, 228-1881, 2109- 22059 mg/m³)
No. of animals per sex per dose:
13
Control animals:
not specified

Results and discussion

Any other information on results incl. tables

Symptoms:

 

At the low concentration, salivation, irregular respiration, dyspnoea, cough, lacrimation and sedation were observed. At the intermediate concentration, immediate agitation, reduced/irregular breathing, cough, sneezing, breathing through open mouth, foamy salivation, nasal discharge, rhinitis, conjunctivitis, dyspnoea and weightloss were apparent. At the high concentration, effects were comparable to those at the intermediate concentration, but were earlier in onset and more severe, Deaths also occurred in this group.


Necropsy:
low dose:
discoloration of nasal cavity, injection of trachea, lung
oedema, ecchymosis, medium dose: corneal opacity, conjunctivitis, nasal corrosion, trachea contain foamy red liquid, oedema of epiglottis, severe emphysema
high dose: as medium dose

Applicant's summary and conclusion

Executive summary:

Acute inhlation exposure of cats to concentrations PCl3 for up to 10 hours resulted in a number of signs of toxicity, which were reported to be similar to those seen with HCl.