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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1969
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given (comparable to standards). Equivalent or similar to OECD guideline. Non GLP

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VII
Author:
Smyth, H.F. et al.
Year:
1969
Bibliographic source:
American Industrial Hygiene Association Journal: 30(5), 470 - 476
Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VI
Author:
Smyth, H.F. et al.
Year:
1962
Bibliographic source:
American Industrial Hygiene Association Journal: 23(2), 95 - 107

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
not specified
Principles of method if other than guideline:
Penetration of rabbit skin is estimated by a technique closely akin to the one-day cuff method of Draize, using groups of four male albino New Zealand rabbits. The fur is removed from the entire trunk by clipping, and the dose is retained beneath an impervious plastic film. The animals are immobilized during the 24-hour contact period, after which the film is removed, the rabbits are caged for the subsequent 14-day observation period and the LD50 is determined.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Allyl methacrylate
EC Number:
202-473-0
EC Name:
Allyl methacrylate
Cas Number:
96-05-9
Molecular formula:
C7H10O2
IUPAC Name:
prop-2-en-1-yl 2-methylprop-2-enoate
Test material form:
other: liquid

Test animals

Species:
rabbit
Strain:
other: albino New Zealand rabbits
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 2.5 - 3.5 kg

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Details on dermal exposure:
REMOVAL OF TEST SUBSTANCE
- Washing: yes (not further specified)
- Time after start of exposure: 24 hours

Duration of exposure:
24 h
Doses:
no data
No. of animals per sex per dose:
4 male animals
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
Statistics:
no data

Results and discussion

Preliminary study:
no data
Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
467 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 345 - 635 mg/kg bw (= 0.5 mL/kg and 0.37 - 0.68 mL/kg, respectively)
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: other: CLP, EU GHS (Regulation (EC) No 1272/2008)
Conclusions:
In a standard acute dermal toxicity test the LD50 of Allyl methacrylate was reported to be 467 mg/kg.
Executive summary:

In a standard acute dermal toxicity test reported in 1969 with 4 male Albino New Zealand rabbits for 24 hours exposure under occlusive conditions the LD50 of Allyl methacrylate was reported to be 467 mg/kg.