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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vitro / ex vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1997
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Adopted according to OECD SIDS (public available peer reviewed source).

Data source

Reference
Reference Type:
secondary source
Title:
Structure-activity Relationships in the Hydrolysis of Acrylate and Methacrylate Esters by Carboxylesterase In Vitro.
Author:
McCarthy, T.J. and Witz, G.
Year:
1997
Bibliographic source:
Toxicol., 116: 153-158; cited in OECD SIDS IUCLID data set (06.05.2009)

Materials and methods

Objective of study:
other: hydrolysis
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Hydrolysis of Acrylate Esters by Porcine Liver Carboxylesterase was tested in vitro.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Radiolabelling:
no

Results and discussion

Any other information on results incl. tables

Hydrolysis of Acrylate Esters by Porcine Liver Carboxylesterase in vitro:

Esters Km (µM)  Vmax (nmol/min) 
Ethyl acrylate   134 +/- 16.8  9 +/- 2.0
Ethyl methacrylate  159 +/- 90  5.2 +/- 2.5*
Butyl acrylate  33 +/- 8.5*  1.5 +/- 0.8*
 Butyl methacrylate  72 +/- 28*  1.8 +/- 0.6*
 Ethyleneglycol dimethacrylate  64 +/- 24*  6.9 +/- 2.4
 Tetraethyleneglycol dimethacrylate  39 +/- 15*  2.9 +/- 1.0*

* Significantly different (p < 0.05) from ethyl acrylate

Applicant's summary and conclusion