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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vitro / ex vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1997
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Adopted according to OECD SIDS (public available peer reviewed source).

Data source

Reference
Reference Type:
secondary source
Title:
Structure-activity Relationships in the Hydrolysis of Acrylate and Methacrylate Esters by Carboxylesterase In Vitro.
Author:
McCarthy, T.J. and Witz, G.
Year:
1997
Bibliographic source:
Toxicol., 116: 153-158; cited in OECD SIDS IUCLID data set (06.05.2009)

Materials and methods

Objective of study:
other: hydrolysis
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Hydrolysis of Acrylate Esters by Porcine Liver Carboxylesterase was tested in vitro.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl methacrylate
EC Number:
201-297-1
EC Name:
Methyl methacrylate
Cas Number:
80-62-6
Molecular formula:
C5H8O2
IUPAC Name:
methyl methacrylate
Test material form:
other: liquid
Radiolabelling:
no

Results and discussion

Any other information on results incl. tables

Hydrolysis of Acrylate Esters by Porcine Liver Carboxylesterase in vitro:

Esters Km (µM)  Vmax (nmol/min) 
Ethyl acrylate   134 +/- 16.8  9 +/- 2.0
Ethyl methacrylate  159 +/- 90  5.2 +/- 2.5*
Butyl acrylate  33 +/- 8.5*  1.5 +/- 0.8*
 Butyl methacrylate  72 +/- 28*  1.8 +/- 0.6*
 Ethyleneglycol dimethacrylate  64 +/- 24*  6.9 +/- 2.4
 Tetraethyleneglycol dimethacrylate  39 +/- 15*  2.9 +/- 1.0*

* Significantly different (p < 0.05) from ethyl acrylate

Applicant's summary and conclusion