Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1981
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only short report, method / subjects not described. Only english summary, report written in french.

Data source

Reference
Reference Type:
publication
Title:
Irritation et Allergie aux Acrylates et Méthacrylates - Première partie - Monoacrylates et Monométhacrylates Simples
Author:
Cavalier, C., Jelen, G., Hervé-Bazin, B., Foussereau, J.
Year:
1981
Bibliographic source:
Ann. Dermatol. Venereol. (Paris) .: 108, 549 - 556

Materials and methods

Study type:
study with volunteers
Endpoint addressed:
skin irritation / corrosion
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Allyl methacrylate was tested for skin irritation in concentrations of 3 and 10% in olive oil.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Allyl methacrylate
EC Number:
202-473-0
EC Name:
Allyl methacrylate
Cas Number:
96-05-9
Molecular formula:
C7H10O2
IUPAC Name:
prop-2-en-1-yl 2-methylprop-2-enoate
Test material form:
other: liquid

Method

Type of population:
not specified
Subjects:
no data
Ethical approval:
not specified
Route of exposure:
dermal
Reason of exposure:
other: no data
Exposure assessment:
measured

Results and discussion

Clinical signs:
3% allyl methacrylate caused skin irritation (without pustules) at 3 of 11 persons (no results were reported for the 10% solution)

Applicant's summary and conclusion