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EC number: 202-473-0
CAS number: 96-05-9
- GPMT: negative (modified Magnusson-Kligman Test)
- GPMT: negative (according to OECD 406)
- Patch Test: negative
Bodyweight gains of guinea pigs in the
Experimantal Group between day 0 and day 24 were comparable to those
observed in the Control Group animals over the same period.
The test material Methacrylate D'Allyle
(MALLY) was found to be a non-sensitizer in the guinea pig.
are valid in vivo data available for the assessment of the skin
sensitising potential of Allyl methacrylate.
In a guinea pig maximisation test (modified
Magnusson-Kligman-Test; according to GLP) which was reliable with
restrictions Allyl methacrylate was administered intradermal (as a 5%
mixture with arachis oil BP) to each of the 10 female Dunkin-Hartley
guinea pigs in the test group during the three-application induction
phase of the study (Arkema, 1984). After 7 days the epicutaneous
injection of the induction phase followed (with undiluted test
substance, under occlusive conditions). The challenge period was carried
out 2 weeks after the epidermal induction by a piece of filter paper
saturated with the test material (10% in paraffin oil). 24 and 48 hours
after the challenge period no effects were observed both in the test and
in the control groups (Safepharm, 1984).
A second guinea pig maximisation test
(according to OECD 406 and GLP) which was reliable with restrictions
confirmed the negative result of the first assay (C.I.T., 1991). In the
intradermal induction phase Allyl Methacrylate was administered to the
10 male and 10 female Dunkin-Hartley guinea pigs at a concentration of
10% (in paraffin oil). After 7 days the epicutaneous injection of the
induction phase followed (with undiluted test substance, under occlusive
conditions). The challenge period was carried out 2 weeks after the
epidermal induction by a piece of filter paper saturated with the test
material (10% in paraffin).
Additionally, a patch test was conducted in
female Hartley albino guinea pigs (Siddiqui, 1982). Two groups of 10
guinea pigs were subjected to 4 insult patch tests in 10 days either
with Allyl Methacrylate (undiluted) or with the positive control,
dinitrochlorobenzene. No animal that received Allyl Methacrylate showed
a positive result, whereas all animals of the positive control group
showed a positive result.
In addition, allyl methacrylate did not
induce contact sensitivity in guinea pigs using the Polak method
Based on the available data, there is no
indication for a skin sensitising potential of the test substance. Thus,
no classification is warranted according to 67/548/EEC and Regulation
(EC) No 1272/2008 (GHS, CLP), respectively.
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