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EC number: 209-218-2 | CAS number: 561-41-1
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on three hydrolysis studies as-
2. and 3. - GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Analytical monitoring:
- not specified
- Positive controls:
- not specified
- Negative controls:
- not specified
- Transformation products:
- not specified
- Type:
- not specified
- Remarks on result:
- other: 2. Not expected to undergoes hydrolysis.
- Type:
- not specified
- Remarks on result:
- other: 3. lack of hydrolysable fuctional group
- Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, it is concluded that test chemical was considered to be stable in water.
- Executive summary:
Data available for its structurally similar read across chemicals has been reviewed to determine the hydrolysis of the test chemical. The studies are as mentioned below:
In first study it was mentined that Aromatic amines are generally resistant to aqueous environmental hydrolysis therefore,test chemical is not expected to hydrolyze in water.
In another study the test chemical is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions Therefore, test chemical was considered to be stable in water.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, it is concluded that test chemical was considered to be hydrolytically stable.
Reference
Description of key information
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, it is concluded that test chemical was considered to be stable in water.
Key value for chemical safety assessment
Additional information
Data available for its structurally similar read across chemicals has been reviewed to determine the hydrolysis of the test chemical. The studies are as mentioned below:
In first study it was mentined that Aromatic amines are generally resistant to aqueous environmental hydrolysis therefore,test chemical is not expected to hydrolyze in water.
In another study the test chemical is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions Therefore, test chemical was considered to be stable in water.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, it is concluded that test chemical was considered to be hydrolytically stable.
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