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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Data is form experimental study report
Qualifier:
according to
Guideline:
other: Shake Flask Method
Principles of method if other than guideline:
Weight of the chemical substance to dissolve in water to form a homogeneous solution of the solute in the solvent
GLP compliance:
no
Type of method:
flask method
Key result
Water solubility:
150 mg/L
Conc. based on:
test mat.
Temp.:
22 °C
pH:
7.4
Remarks on result:
other: Other details not known

Quantity of the Test Substance

(mg or ml)

 

Volume of water to be added

(mL)

Temperature at which the testing performed

(°C)

Procedures undertaken

Water solubility Value / Range

(in mg/L)

pH of test solution

 

 

100mg

 

 

100ml

 

 

22°C

Mechanical Stirring

24Hrs

 

 

150mg/L

 

 

7.4

Membrane Filtration

Yes performed

 

Hot Air Oven Drying/

Air Drying

Performed at temperature of 550C

Conclusions:
The water solubility value of the test chemical was determined to be 150 mg/l at 22°C.
Executive summary:

The water solubility determination of test chemical was done as per the shake flask method. The water solubility value of the test chemical was determined to be 150 mg/l at 22°C. Based on this value, test chemical was considered to be moderately soluble in water.

Description of key information

Based on the available data from study report the water solubility determination of test chemical was done as per the shake flask method. The water solubility value of the test chemical was determined to be 150 mg/l at 22°C. Based on this value, test chemical was considered to be moderately soluble in water.

Key value for chemical safety assessment

Water solubility:
150 mg/L
at the temperature of:
22 °C

Additional information

Based on the available data from study report the water solubility determination of test chemical was done as per the shake flask method. The water solubility value of the test chemical was determined to be 150 mg/l at 22°C.

In a supporting study, the Water solubility of test chemical by shake flask method was determined to be 130 mg/l at 38°C and 6.2 pH.

Thus, on the basis of available information, the water solubility of test chemical was evaluated to be ranges from 130 to 150 mg/l, indicating that the test chemical was considered to bemoderatelysoluble in water.