Registration Dossier
Registration Dossier
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EC number: 203-639-5 | CAS number: 109-01-3
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 1 000 mg/L
Additional information
The sensitivty of 1-methylpiperazine to microorganisms was tested in two studies. A respiration respiration inhibition test with domestic activated sludge was performed similar to OECD TG 209. No effect to sludge respiration was observed to be 1000 mg/L nomimal during 30 minutes of exposure in these tests. The 30-min EC50 was greater than 1000 mg/L (BASF AG, 1989, report no. 1.0336). In a growth inhibition test with Pseudomonas putida according to Bringmann & Kühn (1980) which is very similar to DIN 38412. part 8. For Pseudomonas putida a 16-h EC10 was derived of 197.7 mg/L. According to Table R.10-6 of the REACH guidance R.10 (ECHA, 2008), the test according to Bringmann & Kühn should only be used if no other tests are available. The PNECmicro-organisms for 1-methylpiperazine will therefore be based on the observed NOEC of 1000 mg/L.
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