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Description of key information

Experimental toxicokinetic study was not available on 1-methylpiperarzine. Information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties, according to the REACH guidance document R7.C (2012).


Chemical and physical properties of 1-methylpiperazine:


- Molecular weight: 100.16 g/mol


-Vapour pressure: 6.7 hPa (20°C)


-Water solubility: fully miscible with water in any ratio


-Log Kow: -0.57


 


Absorption:


Based on the physicochemical characteristics of 1-methylpiperazine, with molecular weight of 100.16 g/mol, a log Kow -0.57 and high water solubility, an oral absorption is expected. A low oral absorption is confirmed by the data acute oral toxicity (LD50 = 2258 mg/kg bw in rats).


According to the value of the vapour pressure (6.7 hPa at 20°C), 1-methylpiperazine is considered to be low volatile. In the acute toxicity, death and clinical signs were observed at the dose of 18.52 mg/L (LD50, IHT). 


Dermal absorption of 1-methyl piperazine is expected due to the low molecular weight and the good miscibility in water. Also the substance is a skin irritant and was identified as a skin sensitizer, so some uptake via the skin surface may possible.


Distribution:


A wide distribution in the tissues of the body would be expected for the 1-methylpipecin due to the low molecular weight and good water solubility.


Metabolism:


No specific information was found on metabolism.


Excretion:


The major routes of excretion from the systemic circulation are the urine (due to the low molecular weight).


 


 


 

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