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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

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Description of key information

Experimental toxicokinetic study was not available on 1-methylpiperarzine. Information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties, according to the REACH guidance document R7.C (2012).

Chemical and physical properties of 1-methylpiperazine:

- Molecular weight: 100.16 g/mol

-Vapour pressure: 6.7 hPa (20°C)

-Water solubility: fully miscible with water in any ratio

-Log Kow: -0.57



Based on the physicochemical characteristics of 1-methylpiperazine, with molecular weight of 100.16 g/mol, a log Kow -0.57 and high water solubility, an oral absorption is expected. A low oral absorption is confirmed by the data acute oral toxicity (LD50 = 2258 mg/kg bw in rats).

According to the value of the vapour pressure (6.7 hPa at 20°C), 1-methylpiperazine is considered to be low volatile. In the acute toxicity, death and clinical signs were observed at the dose of 18.52 mg/L (LD50, IHT). 

Dermal absorption of 1-methyl piperazine is expected due to the low molecular weight and the good miscibility in water. Also the substance is a skin irritant and was identified as a skin sensitizer, so some uptake via the skin surface may possible.


A wide distribution in the tissues of the body would be expected for the 1-methylpipecin due to the low molecular weight and good water solubility.


No specific information was found on metabolism.


The major routes of excretion from the systemic circulation are the urine (due to the low molecular weight).




Key value for chemical safety assessment

Additional information