Registration Dossier
Registration Dossier
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EC number: 203-639-5 | CAS number: 109-01-3
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Experimental toxicokinetic study was not available on 1-methylpiperarzine. Information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties, according to the REACH guidance document R7.C (2012).
Chemical and physical properties of 1-methylpiperazine:
- Molecular weight: 100.16 g/mol
-Vapour pressure: 6.7 hPa (20°C)
-Water solubility: fully miscible with water in any ratio
-Log Kow: -0.57
Absorption:
Based on the physicochemical characteristics of 1-methylpiperazine, with molecular weight of 100.16 g/mol, a log Kow -0.57 and high water solubility, an oral absorption is expected. A low oral absorption is confirmed by the data acute oral toxicity (LD50 = 2258 mg/kg bw in rats).
According to the value of the vapour pressure (6.7 hPa at 20°C), 1-methylpiperazine is considered to be low volatile. In the acute toxicity, death and clinical signs were observed at the dose of 18.52 mg/L (LD50, IHT).
Dermal absorption of 1-methyl piperazine is expected due to the low molecular weight and the good miscibility in water. Also the substance is a skin irritant and was identified as a skin sensitizer, so some uptake via the skin surface may possible.
Distribution:
A wide distribution in the tissues of the body would be expected for the 1-methylpipecin due to the low molecular weight and good water solubility.
Metabolism:
No specific information was found on metabolism.
Excretion:
The major routes of excretion from the systemic circulation are the urine (due to the low molecular weight).
Key value for chemical safety assessment
Additional information
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