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EC number: 203-639-5 | CAS number: 109-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Experimental toxicokinetic study was not available on 1-methylpiperarzine. Information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties, according to the REACH guidance document R7.C (2012).
Chemical and physical properties of 1-methylpiperazine:
- Molecular weight: 100.16 g/mol
-Vapour pressure: 6.7 hPa (20°C)
-Water solubility: fully miscible with water in any ratio
-Log Kow: -0.57
Absorption:
Based on the physicochemical characteristics of 1-methylpiperazine, with molecular weight of 100.16 g/mol, a log Kow -0.57 and high water solubility, an oral absorption is expected. A low oral absorption is confirmed by the data acute oral toxicity (LD50 = 2258 mg/kg bw in rats).
According to the value of the vapour pressure (6.7 hPa at 20°C), 1-methylpiperazine is considered to be low volatile. In the acute toxicity, death and clinical signs were observed at the dose of 18.52 mg/L (LD50, IHT).
Dermal absorption of 1-methyl piperazine is expected due to the low molecular weight and the good miscibility in water. Also the substance is a skin irritant and was identified as a skin sensitizer, so some uptake via the skin surface may possible.
Distribution:
A wide distribution in the tissues of the body would be expected for the 1-methylpipecin due to the low molecular weight and good water solubility.
Metabolism:
No specific information was found on metabolism.
Excretion:
The major routes of excretion from the systemic circulation are the urine (due to the low molecular weight).
Key value for chemical safety assessment
Additional information
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