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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Description of key information

A realistic worst-case BCF of 3.9 L/kg will be used in risk assessment for 1-methylpiperazine. This value is read-across from a BCF study from piparzine.

Key value for chemical safety assessment

BCF (aquatic species):
3.9 L/kg ww

Additional information

Based on a low log pow value (log Pow= -0.57), no bioaccumulation of 1 -methylpiperazine is expected.

Based on the results a bioaccumulation study with piperazine in Cyprinus carpio (OECD 305C), cited in the EU Risk Assessment report for piperazine, support this conclusion. The bioaccumulation was investigated during 42 days at 25°C, at two test concentrations, 0.1 and 1.0 mg piperazine/L. BCF was determined to be 0.9 at the lower concentration, <3.9 at the higher concentration. Considering the limit difference in measured log Kow and the strong similarities between both structures it is considered justified to use the highest observed value for read across from the source chemical piperazine to the target chemical 1 -methylpiperazine. The higher BCF of 3.9 L/kg will as a worst-case be used in risk assessment for the evaluation of 1 -methyl piperazine.