Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-417-8 | CAS number: 106-63-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Isobutyl acrylate is acutely toxic to freshwater fish. Based on data from the structural analogue n-butyl acrylate, iBA is estimated to be also acutely toxic to saltwater fish.
LC50 (96 h, flow through) = 2.1 mg/L (measured) (Pimephalis promelas, ASTM 1980)
LC50 (96 h, flow through) = 2.1 mg/L (measured) (Cyprinodon variegatus, OECD 203) (n-butyl acrylate)
Key value for chemical safety assessment
Additional information
Isobutyl acrylate was tested in an acute toxicity test with Pimephalis promelas under flow-through conditions. Biological and chemical procedures followed the American Society for Testing and Materials recommendations (ASTM, 1980). The test was repeated once. Based on mean measured concentrations, the 96-hour LC50 was determined to be 2.09 and 2.11 mg/L, respectively. Reported behavioural effects were: hyperactive locomotor activity, overreactivity to outside stimuli, tetany, with no signs of permanent deformities (lordosis/scoliosis) (Russom et al. 1988).
As supporting study, an acute fish test according to the national German standard DIN 38412, part 15 with Leuciscus idus is available. The 96-hour LC50 based on nominal concentrations was approx. 22 mg/L. In this study conducted in open test vessels, under static conditions and without analytical monitoring, the volatility of iBA was not taken into consideration. Thus, this study is only valid with restrictions.
In addition, valid experimental data from the structural analogue n-butyl acrylate are available which support the LC50 of approx. 2.1 mg/L
published by Russom et al. (1988).
The 96-hour LC50 for n-butyl acrylate in rainbow trout was determined to be 5.2 mg/L based on the mean measured concentrations (BAMM, 1990). This study followed OECD Guideline 203 using a flow-through design. Nominal exposure concentrations ranged from 0.438 to 14 mg/L and mean measured concentrations (0 and 96 hrs) ranged from 0.49 to 7.2 mg/L. Behavioral/sublethal effects noted during the study included surfacing, labored respiration, quiescence, on-bottom orientation and loss of equilibrium. A no-effect concentration (NOEC) of n-Butyl Acrylate toxicity to rainbow trout was determined to be 3.8 mg/L, based upon behavioral and sublethal effects at 14 and 7.2 mg/L. The lack of mortality or behavioral/sublethal effects at the test concentrations of 3.8, 1.9, 0.93 and 0.49 mg/L supported this conclusion.
In a saltwater study conducted with n-butyl acrylate in the sheepshead minnow (BAMM, 1996), the 96-hour LC50 was estimated to be 2.1 mg/L. This study was conducted according to OECD Guideline 203 using a flow-through design. The LC50 value was based on analytically determined concentrations. After 96 hours of exposure, mortality was 0, 100 and 100 % in the 1.3, 3.5 and 5.1 mg butyl acrylate/L treatment groups, respectively. Although no mortality was observed in the 1.3 mg butyl acrylate/L treatment group, the majority of the fish were exhibiting clinical signs of toxicity at test termination (e.g., lethargy, erratic swimming and surfacing). Due to the clinical signs of toxicity observed in the 1.3 mg butyl acrylate/L treatment group, the NOEC was considered to be 1.3 mg butyl acrylate/L.
Since isobutyl acrylate is readily biodegradable and of moderate volatility, exclusively effect values based on analytically measured test concentrations are considered valid for hazard assessment purposes.
In addition, a robust data set of acute studies is available from the other members of the acrylic ester category (methyl, 2-ethylhexyl, ethyl, and tert-butyl acrylate).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

Route: .live2