Registration Dossier

Administrative data

Description of key information

Isobutyl acrylate is irritating to the skin. IBA is not irritating to the eyes.

Key value for chemical safety assessment

Additional information

Skin irritation:

Undiluted isobutyl acrylate was applied to the skin of rabbits under occlusive conditions for one minute, 5 minutes, 15 minutes and 20 hours. After 24 hours, well-defined erythema and edema as well as skin petechiae were observed in all exposure groups. Mean erythema scores (24-48-72 hours) for the 15-min and 20-hour exposure were 2.83 and 2.66, respectively. Mean edema scores (24-48-72 hours) for the 15-min and 20-hour exposure were 1.0 and 2.0, respectively. The effects were not fully reversible within 7-9 days. Seven and nine days after the applications, desquamation was observed for the 1-, 5- and 15 -minute and 20-hour applications. (BASF AG 1962).

Thus, isobutyl acrylate was assessed to be irritating to the skin.

Eye irritation:

In an eye irritation study in White Vienna rabbits conducted according to an internal study protocol, 50 µL of the undiluted substance were instilled into the eye of 2 rabbits. The adjacent eyes of the same animals were treated with NaCl and served as control. The eyes were not washed out as recommended by the OECD TG 405. Eye reactions were read after 1, 24, 48 and 72 hours. Slight conjunctivitis (Draize grade 1), slight chemosis (grade 1) and slight corneal opacity (grade 1) were noted after 24 hours. The effects were completely reversible within 48 hours (BASF AG 1962).

Isobutyl acrylate was assessed to be not irritating to the eyes of rabbits.

Respiratory irritation:

In acute toxicity studies vapour concentrations of more than 1000 ppm (corresponding to approx. 5.2 mg/L) were irritating to the skin, eyes, and the respiratory tract (Union Carbide Corporation 1968, 1971).

Justification for classification or non-classification

EU classification according to Annex I of Directive 67/548/EEC: Xi, R 38

GHS classification (GHS UN rev.3, 2009):

- Skin corrosion/irritation: Category 2

- Specific target organ toxicity, Single exposure: Category 3 (May cause respiratory irritation)