Registration Dossier
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EC number: 203-417-8 | CAS number: 106-63-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented study report which meets basic scientific principles.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report Date:
- 1968
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
- Principles of method if other than guideline:
- Four albino rabbits per dose group, 3-5 months of age, were applied with the undiluted test substance under VINYLITE covering to the clipped intact skin of the trunk. In order to prevent the inhalation of vapour from the chemical, the rabbits were placed in a hood with their heads protruding into the room. The animals were immobilized during the 24 hour contact period. Thereafter, excess fluid was removed to prevent ingestion. LD50 was calculated by the moving average method based on a 14-day observation period.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): Isobutyl acrylate
-Supplier: Union Carbide
- Physical state: liquid
- Analytical purity: no data
- Lot/batch No.: 02497
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 3-5 months
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Type of wrap if used: Vinylite (impervious sheeting)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): excess fluid was removed to prevent ingestion, no further data.
- Time after start of exposure: 24 h
- Duration of exposure:
- 24 h
- Doses:
- 0.5, 1, 2 mL/kg bw (corresponding to 445, 890, 1780 mg/kg bw) Calculation to mg/kg bw based on density of the test substance (0.89 g/mL).
- No. of animals per sex per dose:
- 4
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 793 mg/kg bw
- 95% CL:
- 437 - 1 441
- Mortality:
- 0/4, 3/4 and 3/4 animals died in the dose groups of 445, 890, 1780 mg/kg bw, respectively.
- Clinical signs:
- No clinical signs were observed.
- Gross pathology:
- Congestion of the lungs and the abdominal viscera. Mottled liver. Organs of two victims were autolysed.
- Other findings:
- Skin irritation: ecchymosis, edema and marked erythema noted at necropsy
Any other information on results incl. tables
Mortalities:
445 mg/kg bw: 0/4
890 mg/kg bw: 3/4 (2, 4 days to death)
1780 mg/kg bw: 3/4 (1,2,3 days to death)
Original values reported: LD50 = 0.891 (0.491 -1.62) mL/kg bw which corresponds to ca. 793 (437 - 1441) mg/kg bw.
The test substance produced moderate acute toxicity by covered dermal application for 24 h in rats.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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