Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Additional information:

There are no experimental data on the sensitization potential of isobutyl acrylate available. The structural analogue n-Butyl acrylate on the other hand has been investigated in depth. Thus, an assessment of the potential skin sensitising properties of isobutyl acrylate by read-across is possible.

n-Butyl acrylate was investigated in a Local Lymphnode Assay conducted according to OECD guideline 429 and GLP regulations (BAMM 2006). The application of the test substance at concentrations of 1, 2.5, 5, 10, or 25 % w/v in acetone : olive oil (4:1) resulted in an increase in isotope incorporation which was greater than 3-fold at the 25 % w/v concentration. Consequently, the test substance was shown to be a potential skin sensitiser. The concentration giving rise to a 3 fold increase in lymphocyte proliferation (EC3) was calculated to be 11.2 % w/v (2800 μg/cm2), indicative of a sensitiser of weak potency.

In addition, n-butyl acrylate was tested in guinea pigs and mice using a variety of methods and gave a positive response in most of the tests. For risk assessment purposes and DNEL derivation, the LLNA (BAMM 2006) is the most appropriate study.

Based on the structural similarities of isobutyl acrylate and n-butyl acrylate it is anticipated that isobutyl acrylate will likely show skin sensitizing potential. According to current EU regulations, isobutyl acrylate is classified as sensitizing.

Migrated from Short description of key information:
After repeated skin contact with Isobutyl acrylate sensitization is possible.

Respiratory sensitisation

Endpoint conclusion
Additional information:

There is no information available on the potential for isobutyl acrylate to produce respiratory sensitisation in animals.

Justification for classification or non-classification

EU classification according to Annex I of Directive 67/548/EEC: Xi, R43

GHS classification (GHS UN rev.3, 2009):

- Skin Sensitization Category 1B