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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: limited but acceptable documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973

Materials and methods

Principles of method if other than guideline:
other: eye irritation study
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(morpholinothio)benzothiazole
EC Number:
203-052-4
EC Name:
2-(morpholinothio)benzothiazole
Cas Number:
102-77-2
Molecular formula:
C11H12N2OS2
IUPAC Name:
2-(morpholin-4-ylsulfanyl)-1,3-benzothiazole
Details on test material:
Santocure MOR, Lot no. NC 01-001

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
no
Duration of treatment / exposure:
24 h
Observation period (in vivo):
up to 168 h
Number of animals or in vitro replicates:
6

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24, 48, 72 h
Score:
6
Max. score:
110
Reversibility:
fully reversible within: 120 h
Remarks on result:
other: classed as an eye irritant according to F.H.S.A.

Any other information on results incl. tables

Immediate: Slight discomfort

10 min.: moderate to severe erythema, copious discharge

1 h: moderate to severe erythema, copious discharge

24 h: severe erythema, copious discharge containing whitish exudate (mean score 12/110)

48 to 72 h: gradual improvement (mean score 5 and 1 at 48 h and 72 h, respectively)

168 h: all scored zero

168 h mean score: 0

Effects reversible within 168 h

Classed as an eye irritant according to Federal Hazardous substances Act (F.H.S.A.)

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information