Registration Dossier
Registration Dossier
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EC number: 203-052-4 | CAS number: 102-77-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
Materials and methods
- Principles of method if other than guideline:
- other: acute oral toxicity study
- GLP compliance:
- no
- Test type:
- other: acute oral toxicity study
- Limit test:
- no
Test material
- Reference substance name:
- 2-(morpholinothio)benzothiazole
- EC Number:
- 203-052-4
- EC Name:
- 2-(morpholinothio)benzothiazole
- Cas Number:
- 102-77-2
- Molecular formula:
- C11H12N2OS2
- IUPAC Name:
- 2-(morpholin-4-ylsulfanyl)-1,3-benzothiazole
- Details on test material:
- Santocure MOR, Lot no. NC 01-001
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 5010, 6310, 7940 mg/kg bw
- No. of animals per sex per dose:
- 2 to 3 per dose and sex
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 7 940 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Signs of intoxication: reduced appetite and activity (one to three days in survivors), increasing weakness, collapse and death
Any other information on results incl. tables
Mortality:
5010 mg/kg bw: m (0/2), f (0/3)
6310 mg/kg bw: m (0/3), f (0/2)
7940 mg/kg bw: m (0/2), f (1/3) ( time of mortality: 2 days)
Signs of intoxication: reduced appetite and activity (one to three days in survivors), increasing weakness, collapse and death
Gross autopsy decedents: hemorrhagic lungs and liver and acute gastrointestinal inflammation
survivors (7 days): viscera appeared normal
Applicant's summary and conclusion
- Executive summary:
LD50 rat: higher than 7940 mg/kg bw
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