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Registration Dossier
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EC number: 203-052-4 | CAS number: 102-77-2
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable well-documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- other: Repeated Insult Patch Test modified Shelanski (4 x 4 Method)
Test material
- Reference substance name:
- 2-(morpholinothio)benzothiazole
- EC Number:
- 203-052-4
- EC Name:
- 2-(morpholinothio)benzothiazole
- Cas Number:
- 102-77-2
- Molecular formula:
- C11H12N2OS2
- IUPAC Name:
- 2-(morpholin-4-ylsulfanyl)-1,3-benzothiazole
- Details on test material:
- N-oxydiethylene-benzothiazole sulphenamide, brown granules
Constituent 1
Method
- Type of population:
- general
- Route of administration:
- dermal
Results and discussion
- Results of examinations:
- irritation: 31/49 individuals
sensitizing: 24/49 individuals
Any other information on results incl. tables
Irritation:
The test material elicited irritation in 31/49 individuals.This was well over 50 % of the panelists participating in the study. Minimal or moderate erythema was the extent of irritation in seven (7/49) of these individuals, the picture in the remaining 24 individuals was quite different.
Sensitizing:
During induction phase: 24 individuals (24/49) showed intensive or very intense irritation, consisting of erythema, induration, weeping, and extension beyond the margin of the contact site. The characteristics of these responses were consistent with that of a sensitizing effect.
Applicant's summary and conclusion
- Executive summary:
The test substance (75 % preparation in pet.) induced a allergic response in 24/49 human volunteeres (Monsanto Co.1982).
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