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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: limited but acceptable documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973

Materials and methods

Principles of method if other than guideline:
other: acute dermal toxicity study
GLP compliance:
no
Test type:
other:
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(morpholinothio)benzothiazole
EC Number:
203-052-4
EC Name:
2-(morpholinothio)benzothiazole
Cas Number:
102-77-2
Molecular formula:
C11H12N2OS2
IUPAC Name:
2-(morpholin-4-ylsulfanyl)-1,3-benzothiazole
Details on test material:
Santocure MOR, Lot no. NC 01-001

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
not specified
Vehicle:
corn oil
Duration of exposure:
24 h
Doses:
3160, 5010, 7940 mg/kg bw
No. of animals per sex per dose:
1 to 2 animals per dose
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 7 940 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Signs of intoxication: reduced appetite and activity for one to three days

Any other information on results incl. tables

Mortality: no mortality in any of the treated animals

Signs of intoxication: reduced appetite and activity for one to three days

Gross autopsy (14 days): viscera appeared normal

Applicant's summary and conclusion

Executive summary:

LD50 rabbit: higher than 7940 mg/kg bw