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Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
specific investigations: biochemical or cellular interactions
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1991
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Not assignable; Insufficient detail in the IUCLID entry to determine reliability.
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
Boashevskaya, T.I. et al.
Year:
1991
Bibliographic source:
Gig. Sanit., 58 - 61

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
not applicable
GLP compliance:
not specified
Type of method:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
as described in IUCLID 1.1-1.4

Test animals

Species:
other: no data
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
inhalation
Vehicle:
not specified
Details on exposure:
no data
Analytical verification of doses or concentrations:
not specified
Details on analytical verification of doses or concentrations:
no data
Duration of treatment / exposure:
3 months
Frequency of treatment:
no data
Post exposure period:
not applicable
Doses / concentrations
Remarks:
Doses / Concentrations:
10 mg/m3
Basis:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data

Examinations

Examinations:
no data
Positive control:
no data

Results and discussion

Details on results:
Inhalational exposure of 1,2-dichloropropane in concentration 10 mg/m3 for 3 months induced an increased lipid content in the cells of the adrenalgland cortex.

Any other information on results incl. tables

none

Applicant's summary and conclusion

Conclusions:
Inhalational exposure of 1,2-dichloropropane in concentration 10 mg/m3 for 3 months induced an increased lipid content in the cells of the adrenalgland cortex.
Executive summary:

Inhalational exposure of 1,2-dichloropropane in concentration 10 mg/m3 for 3 months induced an increased lipid content in the cells of the adrenal gland cortex.