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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Specific investigations: other studies

Currently viewing:

Administrative data

Endpoint:
biochemical or cellular interactions
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1991
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Not assignable; Insufficient detail in the IUCLID entry to determine reliability.
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
Boashevskaya, T.I. et al.
Year:
1991
Bibliographic source:
Gig. Sanit., 58 - 61

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
not applicable
GLP compliance:
not specified
Type of method:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-dichloropropane
EC Number:
201-152-2
EC Name:
1,2-dichloropropane
Cas Number:
78-87-5
Molecular formula:
C3H6Cl2
IUPAC Name:
1,2-dichloropropane
Details on test material:
as described in IUCLID 1.1-1.4

Test animals

Species:
other: no data
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
inhalation
Vehicle:
not specified
Details on exposure:
no data
Analytical verification of doses or concentrations:
not specified
Details on analytical verification of doses or concentrations:
no data
Duration of treatment / exposure:
3 months
Frequency of treatment:
no data
Post exposure period:
not applicable
Doses / concentrations
Remarks:
Doses / Concentrations:
10 mg/m3
Basis:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data

Examinations

Examinations:
no data
Positive control:
no data

Results and discussion

Details on results:
Inhalational exposure of 1,2-dichloropropane in concentration 10 mg/m3 for 3 months induced an increased lipid content in the cells of the adrenalgland cortex.

Any other information on results incl. tables

none

Applicant's summary and conclusion

Conclusions:
Inhalational exposure of 1,2-dichloropropane in concentration 10 mg/m3 for 3 months induced an increased lipid content in the cells of the adrenalgland cortex.
Executive summary:

Inhalational exposure of 1,2-dichloropropane in concentration 10 mg/m3 for 3 months induced an increased lipid content in the cells of the adrenal gland cortex.