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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
other: review
Adequacy of study:
key study
Study period:
1986
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data from handbook or collection of data.
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
Monograph for 1,2-dichloropropane.
Author:
IARC
Year:
1999
Bibliographic source:
Monographs on the Evaluation of Carcinogenic Risks to Humans; Volume 71: Re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide (part three), IARC, Lyon, pp 1393 - 1400. IARC Monographs Supplement 7

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-dichloropropane
EC Number:
201-152-2
EC Name:
1,2-dichloropropane
Cas Number:
78-87-5
Molecular formula:
C3H6Cl2
IUPAC Name:
1,2-dichloropropane
Details on test material:
Test substance: 1,2-Dichloropropane

Method

Target gene:
no data
Test concentrations with justification for top dose:
no data
Vehicle / solvent:
no data
Details on test system and experimental conditions:
Type: Ames test
Evaluation criteria:
no data
Statistics:
no data

Results and discussion

Additional information on results:
No data

Any other information on results incl. tables

None

Applicant's summary and conclusion

Conclusions:
1,2 Dichloropropane was mutagenic to Salmonella typhimurium but not to Streptomyces coelicolor.
Executive summary:

1,2 Dichloropropane was mutagenic to Salmonella typhimurium but not to Streptomyces coelicolor. It induced mutations weakly but not chromosomal effects in Aspergillus nidulans. It did not induce sex-linked recessive lethal mutations in Drosophila melanogaster.