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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
other: publication
Adequacy of study:
key study
Study period:
1962
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Early (pre-guideline) study. Methods and results briefly reported. Generally acceptable for assessment.
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Range-finding toxicity data: List VI.
Author:
Smyth, HF, Carpenter, CP, Weil, CS, Pozzani, UC and|Streigel, JA
Year:
1962
Bibliographic source:
Ind Hyg J, March-April 1962, 95 - 107.
Reference Type:
publication
Title:
Range-finding toxicity data: List VII.
Author:
Smyth, HF, Carpenter, CP, Weil, CS, Pozzani, UC, Streigel,|JA and Nycum, JS
Year:
1969
Bibliographic source:
Am Ind Hyg Assoc J, Sept-Oct 1969, 470 - 476.

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
None specified
GLP compliance:
no
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 1,2-Dichloropropane.

Test animals

Species:
rat
Strain:
other: Carforth-Wistar
Sex:
male/female
Details on test animals and environmental conditions:
No data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
The acute oral toxicity of PDC was determined in groups of non-fasted Carworth-Wistar rats (males and females, 4-5 wk old, non-fasted).
Doses:
PDC was administered undiluted, and doses were arranged in a logarithmic series and differed by a factor of two.
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
Statistics:
Animals were observed for 14 d post-treatment, and the LD50 calculated using the methods of Thompson (Bacteriol. Rev. (1947) 11, 115) and Weil (Biometrics (1952) 8, 249). The result is presented as the mean and SD.

Results and discussion

Preliminary study:
No data
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2 200 mg/kg bw
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Any other information on results incl. tables

Acute oral LD50 = 1.9 ± 0.2 ml/kg (mean and SD)

This is equivalent to 2200 ± 230 mg/kg bw, based on a density of 1.155 g/ml [Source: MacKay et al (1993) Illustrated Handbook of Physical-Chemical Properties and Environmental Fate for Organic Chemicals, Vol III, p479]

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Based on the results of the study, PDC is of relatively low inherent toxicity and not classified according to EU criteria.
Executive summary:

The acute oral toxicity of PDC was determined in groups of non-fasted Carworth-Wistar rats (males and females, 4-5 wk old, non-fasted). PDC was administered undiluted, and doses were arranged in a logarithmic series and differed by a factor of two. Animals were observed for 14 d post-treatment, and the LD50 calculated using the methods of Thompson (Bacteriol. Rev. (1947) 11, 115) and Weil (Biometrics (1952) 8, 249). The result is presented as the mean and SD.

Acute oral LD50 = 1.9 +/- 0.2 ml/kg (mean and SD).

This is equivalent to 2200 mg/kg bw, based on a density of1.155 g/ml [Source: MacKay et al (1993) Illustrated Hand book of Physical Chemical Properties and Environmental Fate for Organic Chemicals, Vol III, p479].

Based on the results of the study, PDC is of relatively low inherent toxicity and not classified according to EU criteria.