Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1969
Reliability:
2 (reliable with restrictions)
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Range-finding toxicity data: List VII.
Author:
Smyth, HF, Carpenter, CP, Weil, CS, Pozzani, UC, Streigel,|JA and Nycum, JS
Year:
1969
Bibliographic source:
Am Ind Hyg Assoc J, Sept-Oct 1989, 470 - 476.
Reference Type:
publication
Title:
Chemical burns of the rabbit cornea
Author:
Carpenter, C.P., Smyth, H.F.
Year:
1946
Bibliographic source:
Am. J. Ophthalmol. 25,|1363 - 1

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Method: other: Eye Irritation
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: 1,2 Dichloropropane

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
0.5 ml- undiluted
Duration of treatment / exposure:
No data
Observation period (in vivo):
No data
Number of animals or in vitro replicates:
No data
Details on study design:
Eye injury in rabbits is recorded in a 10-grade ordinal series and is based upon the degree of corneal necrosis that results from instillation of verious volumes and concentrations of chemical. Grade 1 indicates at most a very small area of necrosis resulting from 0.5ml of undiluted chemical in the eye. Grade 5 indicates a so-called sever burn from 0.005ml, and grade 10 indicates a sever burn from 0.5ml of a 1% solution in water or propylene glycol.

Results and discussion

In vivo

Irritant / corrosive response data:
Grade 2: slight irritation response
Other effects:
No data

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Based on the results of the study irritation index is 2 of 10 maximum and test material is slightly irritating to the eye.
Executive summary:

Based on the results of the study irritation index is 2 of 10 maximum and test material is slightly irritating to the eye.