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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1969
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This study was conducted prior to GLP and test guidelines. Methods presented in separate (1962) publication.
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
A Range-finding toxicity data: List VII
Author:
Smyth et al
Year:
1969
Bibliographic source:
American Industrial Hygiene Association Journal. 1969; 30; 470-476
Reference Type:
publication
Title:
No information
Author:
Smyth et al
Year:
1962
Bibliographic source:
American Industrial Hygiene Association Journal. 1962; 23; 95-107

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
One-day cuff method of Draize and associates.
GLP compliance:
no
Test type:
other:
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name of test material (as cited in publication): 1,2-Dichloropropane

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 2.5 to 3.5 kg

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Area of exposure: Trunk
- Type of wrap if used: Impervious plastic film
Duration of exposure:
24 hours
Doses:
No data
No. of animals per sex per dose:
No data
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: no
Statistics:
No data

Results and discussion

Preliminary study:
No data
Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
10 100 mg/kg bw
Mortality:
No data
Clinical signs:
No data
Body weight:
No data
Gross pathology:
No data
Other findings:
No data

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Under the conditions of the study, the dermal LD50 for PDC in male rabbits was 8.75 ml/kg bw (10100 mg/kg bw).
Executive summary:

PDC was applied to clipped skin of male albino rabbits (2.5 - 3.5 kg) under occlusion for 24 hr. The animals were immobilised during expoure, then returned to their cages and observed for 14 days.

An LD50 of 8.75 ml/kg bw was reported. This is equivalent to 10,100 mg/kg bw, based on a density of 1.155 g/ml  [Source: MacKay et al (1993) Illustrated Handbook of Physical-Chemical Properties and Environmental Fate for Organic Chemicals, Vol III, p479]

Under the conditions of the study, the dermal LD50 for PDC in male rabbits was 8.75 ml/kg bw (10100 mg/kg bw); which according to EU

criteria is not classified.