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Registration Dossier
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EC number: 201-152-2 | CAS number: 78-87-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1969
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted prior to GLP and test guidelines. Methods presented in separate (1962) publication.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- A Range-finding toxicity data: List VII
- Author:
- Smyth et al
- Year:
- 1 969
- Bibliographic source:
- American Industrial Hygiene Association Journal. 1969; 30; 470-476
- Reference Type:
- publication
- Title:
- No information
- Author:
- Smyth et al
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal. 1962; 23; 95-107
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- One-day cuff method of Draize and associates.
- GLP compliance:
- no
- Test type:
- other:
- Limit test:
- no
Test material
- Reference substance name:
- 1,2-dichloropropane
- EC Number:
- 201-152-2
- EC Name:
- 1,2-dichloropropane
- Cas Number:
- 78-87-5
- Molecular formula:
- C3H6Cl2
- IUPAC Name:
- 1,2-dichloropropane
- Details on test material:
- Name of test material (as cited in publication): 1,2-Dichloropropane
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 to 3.5 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Trunk
- Type of wrap if used: Impervious plastic film - Duration of exposure:
- 24 hours
- Doses:
- No data
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: no - Statistics:
- No data
Results and discussion
- Preliminary study:
- No data
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 10 100 mg/kg bw
- Mortality:
- No data
- Clinical signs:
- other: No data
- Gross pathology:
- No data
- Other findings:
- No data
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the study, the dermal LD50 for PDC in male rabbits was 8.75 ml/kg bw (10100 mg/kg bw).
- Executive summary:
PDC was applied to clipped skin of male albino rabbits (2.5 - 3.5 kg) under occlusion for 24 hr. The animals were immobilised during expoure, then returned to their cages and observed for 14 days.
An LD50 of 8.75 ml/kg bw was reported. This is equivalent to 10,100 mg/kg bw, based on a density of 1.155 g/ml [Source: MacKay et al (1993) Illustrated Handbook of Physical-Chemical Properties and Environmental Fate for Organic Chemicals, Vol III, p479]
Under the conditions of the study, the dermal LD50 for PDC in male rabbits was 8.75 ml/kg bw (10100 mg/kg bw); which according to EU
criteria is not classified.
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