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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1969
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study conducted prior to guidelines
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
Range-finding toxicity data: List VII.
Author:
Smyth, HF, Carpenter, CP, Weil, CS, Pozzani, UC, Streigel, JA and Nycum, JS
Year:
1969
Bibliographic source:
Am Ind Hyg Assoc J, Sept-Oct 1989, 470 - 476.

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Method: other: Acute Dermal Irritation
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-dichloropropane
EC Number:
201-152-2
EC Name:
1,2-dichloropropane
Cas Number:
78-87-5
Molecular formula:
C3H6Cl2
IUPAC Name:
1,2-dichloropropane
Details on test material:
- Name of test material (as cited in study report): 1, 2 Dichloropropane

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
No data

Test system

Type of coverage:
other: non occlusive
Preparation of test site:
shaved
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
Dermal application on shaved abdominal skin (nonocclusive); effect time: 24 hours
Duration of treatment / exposure:
24 hours
Observation period:
No data
Number of animals:
No data
Details on study design:
Primary skin irritation on rabbits is recorded in a 10-grade ordinal series and is based upon the severest reaction that develops on the clipped skin of each of five albino rabbits within 24 hours of the uncovered application of 0.01ml of undiluted sample or of solutions in water, propylene glycol, or acetone. Grade 1 indicates no irritation and Grade 2 the least visible capillary injection from the undiluted chemical. Grade 6 indicates necrosis when undiluted and Grade 10 indicates necrosis from a 0.01% solution.

Results and discussion

In vivo

Irritant / corrosive response data:
Grade 1: no irritation
Other effects:
No data

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Based on the results of the study, 1, 2 Dichloropropane is not irritating to skin.
Executive summary:

Based on the results of the study, 1, 2 Dichloropropane is not irritating to skin.