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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The read across chemical sodium lauryl sulphate has been identified as 80-90% structurally similar with target chemical sodium 2-(2-dodecyloxyethoxy) ethyl sulphate.This read across further screened in a two stage approach, first stage where in the generic categorisation is done based upon the functional group and mechanistic approach. In the second stage; the read across chemical is further screened based upon endpoint specific criteria. In addition, the target chemical and the read across substance have density and Log Kow values in a narrow range. Thus, they are expected to exhibit comparable toxic or alternatively non-toxic profile.

Data source

Reference
Reference Type:
publication
Title:
SALMONELLA MUTAGENICITY TESTS: II. RESULTS FROM THE TESTING OF 270 CHEMICALS
Author:
MORTELMANS,K, HAWORTH,S, LAWLOR,T, SPECK,W, TAINER,B AND ZEIGER,E
Year:
1986
Bibliographic source:
ENVIRON. MUTAGEN. 8(SUPPL. 7):1-119, 1986

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from ENVIRON. MUTAGEN.
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium dodecyl sulphate
EC Number:
205-788-1
EC Name:
Sodium dodecyl sulphate
Cas Number:
151-21-3
Molecular formula:
C12H25NaO4S
IUPAC Name:
sodium dodecyl sulfate
Details on test material:
- Name of test material : Sodium Lauryl Sulphate (sodium dodecyl sulphate)
- Substance type: Organic
- Physical state: Solid

Method

Species / strain
Species / strain / cell type:
S. typhimurium TA 100
Additional strain / cell type characteristics:
not specified
Metabolic activation:
without
Metabolic activation system:
S9
Test concentrations with justification for top dose:
3-333 UG/PLATE
Vehicle / solvent:
DISTILLED WATER

Results and discussion

Test results
Species / strain:
S. typhimurium TA 100
Metabolic activation:
without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative

Based on the experimental data for in-vitro bacterial reverse mutation assay test on Salmonella typhimurium strain TA 100 without S9 metabolic activation it was estimated that sodium lauryl sulphate does not exhibit positive gene mutation effect.
Executive summary:

Based on the experimental data for in-vitro bacterial reverse mutation assay test on Salmonella typhimurium strain TA 100 without S9 metabolic activation it was estimated that sodium lauryl sulphate does not exhibit positive gene mutation effect.

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