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Short-term toxicity to fish

Based on the various studies available with Klimish rating 2 for the target substance CAS NO 3088-31-1 and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No

Endpoint

Effect values

Basis for effects

Duration

Species

Remarks

1

LC50

25 mg/l

mortality

96 hrs

Danio rerio

Study Report for target chemical

2

LC50

102.59 mg/l

mortality

96 hrs

Danio rerio

Predicted data for target chemical

3

LC50

46 mg/l

mortality

48 hrs

Oryzias latipes

Data from publication for CAS NO 151-21-3

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that the LC50 values was found to be in range of 25 to 102.59mg/l in 96 hrs and 48 hrs on the basis of mortality effect . But the BCF value ofSodium 2-(2-dodecyloxyethoxy) ethyl sulphatereported was not >= 2000 as well as the substance was found to be rapidly degradable. Thus considering the CLP Criteria for aquatic classification of the substance, it is concluded that Sodium 2-(2-dodecyloxyethoxy) ethyl sulphate does not exhibit short term toxicity to fish (Oryzias latipes,Danio rerio)

 

Long term toxicity to fish:

Based on the prediction done using ECOSAR version 1.1, the long term toxicity on fish was predicted for test substance . On the basis of effects observed in a static fresh water system, the NOEC value for the substance is estimated to be36.507mg/l for fish for 28 days of exposure duration.Since, the test substance is redialy degradable in aquatic environment, it can be concluded that the test chemical can be considered as non-toxic to fish at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria. 

Short-term toxicity to aquatic invertebrates

Based on the various studies available with Klimish rating 2 for target chemical CAS NO 3088-31-1 and the read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No

Endpoint

Effect values

Basis for effects

Duration

Species

Remarks

1

LC50

86.09 mg/l

mortality

48 hrs

Daphnia magna

Predicted data for target chemical

2

LC50

7.2 - 154 mg/L.

 

mortality

24 hrs

Artemia salina

Data from publication for CAS no 151-21-3

3

LC50

10.9 – 29.4 mg/L.

 

mortality

24 hrs

Brachionus plicatilis

Data from publication for CAS no 151-21-3

4

LC50

5.1 – 84 mg/L.

 

mortality

24 hrs

Daphnia magna

Data from publication for CAS no 151-21-3

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that LC50 value is expected to be in range of 5.1 to 154 mg/l in a 24 to 48 hrs study on the basis of mortality effect. But the BCF value of Sodium 2-(2-dodecyloxyethoxy) ethyl sulphate reported was not >= 2000 as well as the substance was found to be rapidly degradable. Thus according to CLP criteria of aquatic classification it is concluded that the substance Sodium 2-(2-dodecyloxyethoxy) ethyl sulphate is not toxic to aquatic invertebrate (Daphnia magna, Artemia salina and Brachionus plicatilis)

 

Long term toxicity to aquatic invertebrate:

Based on the prediction done using ECOSAR version 1.1, the long term toxicity on aquatic invertebrate was predicted for test substance . On the basis of effects observed in a static freshwater system, the NOEC value for the test substance is estimated to be 20.059 mg/l for aquatic invertebrate for 21 days of exposure,The test substance is redialy biodegradable in aquatic environment it can be concluded that the test chemical can be considered as non-toxic to aquatic invertebrate at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.

Toxicity to aquatic algae and cyanobacteria

Based on the various studies available with Klimish rating 2 for the target substance CAS NO 3088-31-1 and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No

Endpoint

Effect values

Basis for effects

Duration

Species

Remarks

1

EC50

115.072mg/l

growth rate

72 hrs

Pseudokirchnerella subcapitata

Predicted data for target chemical

2

EC50

100 mg/l

Cell changes

24 hrs

Laminaria hyperborea

Data from publication for CAS no 9004-82-4

3

EC50

117mg/l

growth inhibition

4 days

Seleriastrum Capricornutum

Data from publication for CAS no 151-21-3

4

EC50

1550mg/l

growth inhibition

6 hrs

Seleriastrum Capricornutum

Data from publication for CAS no 151-21-3

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that EC50 value is expected to be in range of100 to1550 mg/l in 6 hrs to 72 hrs study. Thus considering CLP Criteria for aquatic classification of the substance, it is concluded that Sodium 2-(2-dodecyloxyethoxy) ethyl sulphate does not exhibit toxicity to green algae (Pseudokirchnerella subcapitata, Laminaria hyperborea  and Seleriastrum Capricornutum.)

Toxicity to microorganisms

Based on the various studies available with Klimish rating 2 for the target substance CAS NO 3088-31-1 and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No

Endpoint

Effect values

Basis for effects

Duration

Species

Remarks

1

IC50

5888.99 mg/l

growth inhibition

16 hrs

aerobic microorganisms

Predicted data for target chemical

2

EC50

 

 

EC50

135 mg/l

 

 

188 mg/l

growth inhibition

3 hrs

 

 

0.5 hrs

activated sludge

Data from publication for CAS no 151-21-3

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that IC50 value is expected to be in 5888.99mg/l and EC50 value was found to be in the range of 135 to 188 mg/l in 0.5 to 16 hrs study.

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