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Toxicity to microorganisms

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Description of key information

From QSAR prediction the bacterial growth inhibition test using aerobic microorganisms as the end point, the substance sodium 2-(2-dodecyloxyethoxy) ethyl sulphate was not found to inhibit growth by 50% up to the maximum tested concentration (IC50) of 5888.99 mg/l.

Key value for chemical safety assessment

EC50 for microorganisms:
5 888.99 mg/L

Additional information

Based on the various studies available with Klimish rating 2 for the target substance CAS NO 3088-31-1 and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No

Endpoint

Effect values

Basis for effects

Duration

Species

Remarks

1

IC50

5888.99 mg/l

growth inhibition

16 hrs

aerobic microorganisms

Predicted data for target chemical

2

EC50

 

 

EC50

135 mg/l

 

 

188 mg/l

growth inhibition

3 hrs

 

 

0.5 hrs

activated sludge

Data from publication for CAS no 151-21-3

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that IC50 value is expected to be in 5888.99mg/l and EC50 value was found to be in the range of 135 to 188 mg/l in 0.5 to 16 hrs study.

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