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Short-term toxicity to fish

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Link to relevant study record(s)

Description of key information

A 96 h study was conducted for Sodium 2-(2-dodecyloxyethoxy) ethyl sulphate on Danio rerio, at a test concentration of 12.5mg/L, 25 mg/L, 50 mg/L, 75 mg/L & 100 mg/L. Based on nominal concentrations, the median lethal concentration LC50 (96 h) for Sodium 2-(2-dodecyloxyethoxy) ethyl sulphate on Danio rerio was found to be 25 mg/L. But the BCF value of Sodium 2-(2-dodecyloxyethoxy) ethyl sulphate reported was not >= 2000 as well as the substance was found to be rapidly degradable. Thus,considering the CLP Criteria for aquatic classification of the substance , it is concluded that sodium 2-(2-dodecyloxyethoxy) ethyl sulphate does not exhibit short term toxicity to fish [Danio rerio].

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
25 mg/L

Additional information

Based on the various studies available with Klimish rating 2 for the target substance CAS NO 3088-31-1 and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No

Endpoint

Effect values

Basis for effects

Duration

Species

Remarks

1

LC50

25 mg/l

mortality

96 hrs

Danio rerio

Study Report for target chemical

2

LC50

102.59 mg/l

mortality

96 hrs

Danio rerio

Predicted data for target chemical

3

LC50

46 mg/l

mortality

48 hrs

Oryzias latipes

Data from publication for CAS NO 151-21-3

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that the LC50 values was found to be in range of 25 to 102.59mg/l in 96 hrs and 48 hrs on the basis of mortality effect . But the BCF value ofSodium 2-(2-dodecyloxyethoxy) ethyl sulphatereported was not >= 2000 as well as the substance was found to be rapidly degradable. Thus considering the CLP Criteria for aquatic classification of the substance, it is concluded that Sodium 2-(2-dodecyloxyethoxy) ethyl sulphate does not exhibit short term toxicity to fish (Oryzias latipes,Danio rerio)

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