Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 446-620-9
CAS number: 120983-72-4
JAU 6476-Chlormethylketon was administered in the diet to 6 male and 6 female Wistar rats per dose group in concentrations of 0, 10, 100 and 500 ppm for a period of 8 weeks. The same number of rats received 1000 ppm starting one week later for 7 weeks.
This study was intended as an exploratory feeding study for the dose selection for a 1 generation study.
Investigations on blood samples were performed. Organs and tissues were subjected to gross and histopathological investigations in liver, spleen, kidney and stomach (done in 0, 10, 100 and 500 ppm rats only). Selected organs (liver, spleen, kidneys) were weighed. The test substance was homogeneously distributable in the diet. Based on analytically established instability of test substance in the diet averaged dose levels of maximally 67, 335 and 670 ppm were roughly estimated for the 100, 500 and 1000 ppm concentrations. Consequently the diet as administration route has turned out to be inadequate.
In summary there were no remarkable effects at 10 ppm except the decrease of liver weights in males, which is not considered to reflect an adverse effect as corresponding histopathologically or biochemical findings are lacking. From 100 ppm onwards effects on the kidneys were evident and APh plasma activities were decreased. At 500 ppm and above body weights, blood parameters and liver were affected and clinical findings indicated poor general condition. At 1000 ppm more prounouced toxicity was evident.
As the test substance had turned out to be strongly instable in the diet caused by its high volatility the outcome of this study is limited (especially for the 10 ppm group) and cannot be used for setting a doubtless NOEL or NOAEL. However, following rough estimations of the decrease of the test substance content during a feeding period of 7 days the concentration of about 67 ppm (instead of 100 ppm) corresponding to 35.0 (males) and 36.3 mg/kg body weight per day (females) could be expected to be the LOAEL under the conditions described.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Deze website maakt gebruik van cookies om het surfen zo aangenaam mogelijk te maken.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again