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EC number: 446-620-9
CAS number: 120983-72-4
Skin sensitization study in vivo:
The Guinea Pig Maximization Test (GPMT) was performed in 2001 on 30 female guinea pigs (20 animals for the test item group and 10 control animals) to determine whether the test item JAU 6476 Chloromethylketone (purity: 92.0%) exhibits skin sensitizing properties.
The challenge with the 0.5% test item formulation led to skin effects (grade 1 - 3) in 20 of 20 animals (100%) in the test item group and no skin effects were seen in the control group animals. In summary, under the conditions of the maximization test and with respect to the evaluation criteria the test item therefore exhibits a skin-sensitization potential.
The Guinea Pig Maximization Test (GPMT) was performed in 2001 on 30 female guinea pigs (20 animals for the test item group and 10 control animals) to determine whether the test item JAU 6476 Chloromethylketone (purity: 92.0%) exhibits skin sensitizing properties. Additional two animals were used for dose-finding. The study was conducted according to OECD Guideline No. 406/EC Guideline 96/54/EC (22th Adaptation of Guideline 67/548/EEC)/Health Effects Test Guideline, OPPTS 870.2600 with the following test item concentrations:
Intradermal induction: 0.1%
Topical induction: 3%
The test item was formulated in corn oil to yield a solution.
Based on the study results for skin sensitization allocation to category 1A (H317) according to Regulation (EC) No. 1272/2008 (CLP), ANNEX I, is warranted.
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