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EC number: 446-620-9
CAS number: 120983-72-4
Under the present test conditions the three rabbits exposed for 4 hours to 0.5 ml JAU 6476-Chloromethylketone/patch and animal (semi-occlusive condition) showed the following effects: An erythema (grade 2) was observed in all animals 1 and 24 hours after patch removal, the test site was pale and indurated with an approx. 2 cm wide dark-red - brown necrotic strip around the test site from 48 hours until 14 days after patch removal (skin destruction). An oedema (grade 1) was observed in all animals 1 and 24 hours after patch removal and an oedema (grade 2) from 48 hours until 14 days after patch removal. There were no systemic intolerance reactions.
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