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EC number: 446-620-9
CAS number: 120983-72-4
Table 2: Summary of acute inhalation toxicity - 4 hour exposure to evaporated testsubstance
N = group assignment, m = males, f = females; a) any number smaller than 5 means that animalssuccumbed during the exposure period, Od: exposure day, ** p < 0.05Values given in the Toxicological results' column are:1st = number of dead animals.2nd = number of animals with signs after cessation of exposure.3rd = number of animals exposed.
A study on the acute inhalation toxicity of 1-Chloro-1-chloroacetylcyclopropane (hereafter referred to as test substance) on rats has been conducted in accordance with OECD Guideline No. 403. Test procedures were adapted so as to comply also with the Directive 92/69/EEC and OPPTS 870.1300. Three groups of rats were nose only exposed to a mean concentrations of 78, 144, 489, and 1975 mg test substance/m3 air.
Observations and Measurements: Vapor concentrations of 78 mg/m3 and above resulted in a concentration-dependent mortality occurring up to the first postexposure day and clinical signs, such as: bradypnea, labored breathing pattern, stridor, rales, dyspnea, serous discharge from nose, nostrils/muzzle with red discolorations and encrustations, periorbicular hyperemia/swelling, corneal opacity, forelimbs reddened, piloerection, ungroomed hair-coat, cyanosis, prostration (ventral position), apathy, motility reduced, reduced reflexes, limp, tremor, hypothermia, emaciation; and decreased body weights. The intensity and duration of clinical signs was governed by respiratory effects. Gross necropsy appears to suggest that mortality was causally related with acute lung edema.
In summary, the evaporated test substance proved to have a high acute inhalation toxicity to rats.
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