Propanol, (2-ethoxymethylethoxy)-

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP guideline study - original study report available

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1986

Report date:

1986

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

5-methyl-4,7-dioxa-2-nonanol

Cas Number:

58797-30-1

Molecular formula:

C8H18O3

IUPAC Name:

5-methyl-4,7-dioxa-2-nonanol

Constituent 2

Reference substance name:

1-(2-ethoxypropoxy)propan-2-ol

EC Number:

233-408-4

EC Name:

1-(2-ethoxypropoxy)propan-2-ol

Cas Number:

10143-32-5

Molecular formula:

C8H18O3

IUPAC Name:

6-methyl-4,7-dioxa-2-nonanol

Details on test material:

- Name of test material (as cited in study report): Dipropylene Glycol Monoethyl Ether
- Substance type: Glycol ether
- Physical state: Clear, colourless liquid
- Lot/batch No.: GOHC Lab. sample No. 1030, Oil Stocks reference No. 08977, 134/109
- Storage condition of test material: Ambient temperature in brown screw cap bottle
- Other:

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles River (UK) Limited
- Age at study initiation: young adult
- Weight at study initiation: male 106-133 g and females 110-133 g
- Fasting period before study: 1 day
- Housing: Type RC1 cages with grid floors
- Diet (e.g. ad libitum): pelleted diet ad libitum
- Water (e.g. ad libitum): tapwater ad libitum
- Acclimation period: 6 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21
- Humidity (%): 55
- Air changes (per hr): 17
- Photoperiod (hrs dark / hrs light): 12/12 h

IN-LIFE DATES: 1985-10-08 to 1985-11-06

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

VEHICLE
None
MAXIMUM DOSE VOLUME APPLIED:
7.56 ml/kg

Doses:

2.76, 3.86, 5.40 and 7.56 ml/kg

No. of animals per sex per dose:

5

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs daily, body weight on days 1, 8 and 14

Statistics:

Probit (Finney 1952)

Results and discussion

Effect levels

Effect levels 1

Sex:

male

Dose descriptor:

LD50

Effect level:

5.5 mL/kg bw

Based on:

test mat.

95% CL:

4.8 - 6.3

Effect levels 2

Sex:

female

Dose descriptor:

LD50

Effect level:

4.5 mL/kg bw

Based on:

test mat.

95% CL:

3.4 - 5.6

Effect levels 3

Sex:

male/female

Dose descriptor:

LD50

Effect level:

5 mL/kg bw

Based on:

test mat.

95% CL:

4.2 - 5.7

Mortality:

see above

Clinical signs:

other: Lethargy, decreased motor activity, prone posture and ataxia or breathing irregularity and unconsciousness. All recovered by day 3.

Gross pathology:

Staining of fur, abnormal GI contents, thymic petechiae and pallor of stomach wall in decedents

Other findings:

No abnormalities

Applicant's summary and conclusion

Interpretation of results:

Category 5 based on GHS criteria

Remarks:

Migrated information

Conclusions:

Slightly toxic.

Executive summary:

After adjustment for relative density (0.9317) the combined male/female LD50 of 5.0 ml/kg and the female LD50 of 4.5 ml/kg (ca 4700 mg/kg and 4200 mg/kg respectively) are above the level for classification as toxic or R22 in EU criteria but are in the range 2000 to 5000 mg/kg for Category 5 Classification under GHS.