Propanol, (2-ethoxymethylethoxy)-

Endpoint summary

Description of key information

Acute p.o. toxicity study in the rat

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Dose descriptor:

LD50

Value:

4 659 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion

Dose descriptor:

discriminating dose

Value:

2 009 mg/kg bw

Justification for classification or non-classification

After adjustment for relative density (0.9317) the combined male/female oral LD50 of 5.0 ml/kg and the female LD50 of 4.5 ml/kg (ca 4659 mg/kg and 4193 mg/kg respectively) are above the level for classification as toxic or R22 under directive 67/548 or for classification under regulation 1272/2008

In a guideline and GLP acute dermal toxicity limit study, the substance ethoxypropoxy propanol did not cause any mortality at a dose of 2009 mg/kg bw. No adverse clinical or pathological observations seen. Classification under directive 67/548 or regulation 1272/2008 is not therefore warranted.