Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Acute p.o. toxicity study in the rat

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
4 659 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
discriminating dose
2 009 mg/kg bw

Additional information

Justification for classification or non-classification

After adjustment for relative density (0.9317) the combined male/female oral LD50 of 5.0 ml/kg and the female LD50 of 4.5 ml/kg (ca 4659 mg/kg and 4193 mg/kg respectively) are above the level for classification as toxic or R22 under directive 67/548 or for classification under regulation 1272/2008

In a guideline and GLP acute dermal toxicity limit study, the substance ethoxypropoxy propanol did not cause any mortality at a dose of 2009 mg/kg bw. No adverse clinical or pathological observations seen. Classification under directive 67/548 or regulation 1272/2008 is not therefore warranted.