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EC number: 405-820-6
CAS number: 30025-38-8
Test substance (dipropylene glycol ethyl ether): inherently
biodegradable based on studies available.
Structural analogues either side in homologous series (dipropylene
glycol methyl ether and dipropylene glycol n-propyl ethe, part of the P
series category: both readily biodegradable.
There are a limited number of degradation studies available on the
substance dipropylene glycol ethyl (DPGEE) ether. In a
guideline OECD301F study, DPGEE was not readily biodegradable, reaching
only 38 -43% by day 28. However, the study showed a long lag phase of 10
-20 days and, more importantly, the reference substance did not reach
the required level of degradation in 14 days required in the study
guideline for the study to be valid. This result can be considered
reliable as an indicator that the substance is degradable but does not
provide unequivocal evidence of ready biodegradability . The
substance was also assessed in a guideline inherent biodegradation
study. A biodegradation rate greater than 70% (98%) in this test
confirmed inherent ultimate biodegradability and therefore low potential
for environmental persistency.
Biodegradation studies have also been performed on the two substances
either side of DPGEE in the homologous series of dipropylene glycol
n-alkyl ethers. Dipropylene glycol methyl ether
(DPGME) was evaluated for ready biodegradability following the OECD
Method 301F. Oxygen consumption and CO2evolution resulting from
biodegradation of the compound was measured over a 28-day test. The
average extent of biodegradation based on O2consumption at the end of
the 10 day window was 75%. The extent of
biodegradation based on CO2production (DCO2) and DOC removal for DPGME
after 28 days was 76% and 96% respectively. DPGME can
be classified as “readily biodegradable”,meeting the 10 day window. In
a guideline and GLP study, the substance dipropylene glycol monopropyl
ether (DPGPE) was found to be readily biodegradable when tested
according to guideline OECD301A study. A degradation of 92% was found at
the end of the 23 day study.
In conclusion, DPGEE is clearly at least inherently biodegradable. In
a ready biodegradation study 38-43% degradation was seen after 28 days
but the innoculum was shown to be below acceptable levels of activity as
the reference substance degraded more slowly than accepted for a valid
study. There is data on the two glycol ethers either
side of DPGEE in the homologous series, DPGME and DPGPE, that show that
both of these substances are readily biodegradable. There
is no credible scientific reason why these should be readily
biodegradable and DPGEE not. Considering the weight of
evidence, it is concluded that DPGEE is likely to be readily
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