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EC number: 405-820-6
CAS number: 30025-38-8
Incidence of liver findings
Dose level (mg/kg/day)
Centrilobular hepatocyte hypertrophy
10 animals examined in all dose groups
Incidence of kidney findings
Cortical tubular eosinophilic inclusions
10 animals examined in all dose groups. No incidence
Statistically significant haematological findings.
Males – mean (SD)
High dose animals
0.22 (0.059), n=14
0.16 (0.036), n=13
Females – mean (SD), n=15
In a guideline and GLP 90 day repeat dose oral gavage toxicity study
using the substance ethoxypropoxy propanol, a no adverse effect level of
1000mg/kg/day was established. The study also included a functional
observation battery and a satellite 4 week recovery group. Observed
effects attributed to treatment included salivation post dosing. At the
end of the study, slight differences were seen in clinical chemistry, in
liver and kidney weight and histopathology and in one of the FOB
parameters. All of these were seen in the high dose animals and were
attributed to treatment. Slight haematological statistically significant
changes were seen but were not attributed to treatment. Of the treatment
related changes seen, all were fully reversed in the recovery group
animals and were therefore regarded as being adaptive and reversible
changes that were not adverse.
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