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Administrative data

Description of key information

According to the available data from oral application. the LD50 (female) = 632 mg/kg bw  was calculated and LD50(male) > 200 mg/kg bw is assumed.

Key value for chemical safety assessment

Additional information

Oral application

Single oral application of 200 mg/kg bw diluted in polyethylene glycole was given to male and female Wistar rats by gavage Since all females that received 2000 mg/kg bw died no males were tested with this dose. Signs of intoxication before death were "spasmic-jumping behaviour" ; 200 mg/kg bw was tolerated by males and females without symptoms. Body weight development was not influenced at the dose of 200 mg/kg bw in both sexes. Post mortem exanination was without findings in 200 mg/kg bw males and females but females that had received 2000 mg/kg bw showed yellow fluid in the stomach and reddened mucosa lstomach and lungs.The approximately LD50 value for female rats was 632 mg/kg bw and the LD50 value for male rats was >200 mg/kg bw (Bayer AG.1995)

Dermal application and inhalation exposure

According to ANNEX VII Section 8.5 of Regulation (EC)1907/2006 (REACH) acute toxicity studies with dermal application or inhalation exposure are not required. In addition, the substance is considered to be corrosive and is classified and labelled accordingly by selfclassification.

Justification for classification or non-classification

Based on the acute oral toxicity data dibenzylamine is classified and labelled R22. harmfull if swallowed according to 67/548/EEC self classification. According to GHS/CLP Regulation (EC)1272/2008 the substance has to be allocatied to category 4, Hazard Statement 302 (Harmful if swallowed).