Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-117-7 | CAS number: 103-49-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- No GLP or OECD defined
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
- Principles of method if other than guideline:
- 500 µl N,N Dibenzylamine was applied to the skin of rabbits for 4 hours to evalutate the skin Irritation/corrosion potential of the test substance (no further data) .
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dibenzylamine
- EC Number:
- 203-117-7
- EC Name:
- Dibenzylamine
- Cas Number:
- 103-49-1
- Molecular formula:
- C14H15N
- IUPAC Name:
- dibenzylamine
- Details on test material:
- IUCLID4 Test substance: other TS: purity 99.1 %
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- body weight: 3.6 kg
- no further data
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 500 µl
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 14 d
- Number of animals:
- 1
- Details on study design:
- Scoring according to Draize, 1h, 24 h, 48 h, 72 h, and 7 d, and 14 days post application
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- other: skin appearance
- Basis:
- animal #1
- Time point:
- other: 7d, 14 d
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: squamous covering, induration of the skin
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 1h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 7 d
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 14 d
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 7 d
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 14 d
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- Due to a severe skin irritation including non-reversible squamous covering and induration of the skin in the first tested animal, no further animals were tested dermally
Any other information on results incl. tables
Results (Exposition time: 4
| Draize Grade after | |||||||||||||||
| G11 | Body weight | 1h | 24h | 48h | 72h | 7d | 14d | Irritation Index | |||||||
| G11 | 3.6 kg | e | o | e | o | e | o | e | o | e | o | e | o | e | o |
| 3 | 3 | 3 | 2 | 3 | 1 | 3 | 1 | 3 | 1 | 3 | 1 | 3.0 | 1.3 | ||
| f,g | f,g | ||||||||||||||
f = white flaked covering ; g = hardening
Applicant's summary and conclusion
- Interpretation of results:
- Category 1C (corrosive) based on GHS criteria
- Conclusions:
- The test substance was tested in one animal for its skin irritative/corrosive potential. Due to a severe skin irritation including non-reversible squamous covering and induration of the skin in the first tested animal, no further animals were tested dermally.
Based of the result of this study the N.N-Dibenzylamine was found to be corrosive to the skin (Bayer 1994).
Based on the criteria of the CLP regulation (EC) No 1272/2008, the test item should be classified for skin corrosion Category 1C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
