Dibenzylamine

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Remarks:

No GLP or OECD defined

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1994

Materials and methods

Principles of method if other than guideline:

500 µl N,N Dibenzylamine was applied to the skin of rabbits for 4 hours to evalutate the skin Irritation/corrosion potential of the test substance (no further data) .

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Dibenzylamine

EC Number:

203-117-7

EC Name:

Dibenzylamine

Cas Number:

103-49-1

Molecular formula:

C14H15N

IUPAC Name:

dibenzylamine

Details on test material:

IUCLID4 Test substance: other TS: purity 99.1 %

Test animals

Species:

rabbit

Strain:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- body weight: 3.6 kg
- no further data

Test system

Type of coverage:

not specified

Preparation of test site:

not specified

Vehicle:

not specified

Controls:

not specified

Amount / concentration applied:

500 µl

Duration of treatment / exposure:

4 h

Observation period:

14 d

Number of animals:

1

Details on study design:

Scoring according to Draize, 1h, 24 h, 48 h, 72 h, and 7 d, and 14 days post application

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

animal #1

Time point:

24/48/72 h

Score:

3

Max. score:

4

Reversibility:

not reversible

Results 2

Irritation parameter:

other: skin appearance

Basis:

animal #1

Time point:

other: 7d, 14 d

Score:

ca. 4

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: squamous covering, induration of the skin

Results 3

Irritation parameter:

edema score

Basis:

animal #1

Time point:

other: 1h

Score:

3

Max. score:

4

Reversibility:

not reversible

Results 4

Irritation parameter:

edema score

Basis:

animal #1

Time point:

24 h

Score:

2

Max. score:

4

Reversibility:

not reversible

Results 5

Irritation parameter:

edema score

Basis:

animal #1

Time point:

48 h

Score:

1

Max. score:

4

Reversibility:

not fully reversible within: 14 days

Results 6

Irritation parameter:

edema score

Basis:

animal #1

Time point:

72 h

Score:

1

Max. score:

4

Reversibility:

not fully reversible within: 14 days

Results 7

Irritation parameter:

edema score

Basis:

animal #1

Time point:

7 d

Score:

1

Max. score:

4

Reversibility:

not fully reversible within: 14 days

Results 8

Irritation parameter:

edema score

Basis:

animal #1

Time point:

14 d

Score:

1

Max. score:

4

Reversibility:

fully reversible within: 14 days

Results 9

Irritation parameter:

erythema score

Basis:

animal #1

Time point:

other: 1 h

Score:

3

Max. score:

4

Reversibility:

not reversible

Results 10

Irritation parameter:

erythema score

Basis:

animal #1

Time point:

7 d

Score:

3

Max. score:

4

Reversibility:

not reversible

Results 11

Irritation parameter:

erythema score

Basis:

animal #1

Time point:

14 d

Score:

3

Max. score:

4

Reversibility:

not reversible

Irritant / corrosive response data:

Due to a severe skin irritation including non-reversible squamous covering and induration of the skin in the first tested animal, no further animals were tested dermally

Any other information on results incl. tables

Results (Exposition time: 4

Draize Grade after

G11

Body weight

1h

24h

48h

72h

7d

14d

Irritation Index

G11

3.6 kg

e

o

e

o

e

o

e

o

e

o

e

o

e

o

3

3

3

2

3

1

3

1

3

1

3

1

3.0

1.3

f,g

f,g

f = white flaked covering ; g = hardening

Applicant's summary and conclusion

Interpretation of results:

Category 1C (corrosive) based on GHS criteria

Conclusions:

The test substance was tested in one animal for its skin irritative/corrosive potential. Due to a severe skin irritation including non-reversible squamous covering and induration of the skin in the first tested animal, no further animals were tested dermally.
Based of the result of this study the N.N-Dibenzylamine was found to be corrosive to the skin (Bayer 1994).
Based on the criteria of the CLP regulation (EC) No 1272/2008, the test item should be classified for skin corrosion Category 1C.