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EC number: 203-117-7
CAS number: 103-49-1
Pharmacokinetics of dibenzylamine was investigated by an intramuscular
injection of 1250 mg of a cefazoline-dibenzylamine-complex into 3
volunteers.Blood and urine content was measured chromatographically in
time intervals up to at least 36 hours.The following determinations were
made: absorption rate constant .33 per hour; half-life of dibenzylamine:
6.33 hours; t(max): 5.23 hours;
C( max): 141.6 ng/ml; Area Under the Curve (AUC): 2296.5 ng h/ml;
urinary excretion: 6.73 %
According to these findings and using the normal dosage interval of 24
h, the degree of accumulation of dibenzylamine between the first dose
and the steady state would be 1.07 (Calvo 1989)
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