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EC number: 203-117-7
CAS number: 103-49-1
N,N-Dibenzylamine metabolism was studied in vitro by incubation of
N,N-dibenzylamine with male rabbit liver 9000g supernatant for 30
minutes. The study has shown that N-oxidation is the major metabolic
process. Of the total amount of dibenzylamine metabolized , 90 % is
converted to N,N-dibenzylhydroxylamine. The primary amine benzylamine is
formed to 6 % of total substrate metabolized. The N-oxidation of the
parent amine was inhibited by CO, SKF525-A, and inhibitors known to
interact with microsomal cytochrom P-450. Phenobarbitone pre-treatment
stimulates further metabolism of the hydroxylamine (Beckett 1975).
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