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EC number: 214-288-2
CAS number: 1119-86-4
Table 1. Summary of results
Test item concentration (μg/mL)
Proliferation index (CBPI)
Micronucleated cells (%)**
Exposure period 4 hrs without S9 mix
Exposure period 20 hrs without S9 mix
Exposure period 4 hrs with S9 mix
For the positive control groups and the test item treatment groups the
values are related to the solvent controls
The number of micronucleated cells was determined in a sample of 2000
number of micronucleated cells is statistically significantly higher
than corresponding control values
Not evaluable due to cell debris
Not determined due to strong cytotoxicity
DMSO 0.5 % (v/v) 2 MMC 1.0 μg/mL
Demecolcin 100.0 ng/mL
CPA 15.0 μg/mL
results and raw data are provided as background information.
The test item
decan-1,2-diol, dissolved in DMSO, was assessed for its potential to
induce micronuclei in human lymphocytes in vitro in the absence
and presence of metabolic activation by S9 mix, in two independent
experiments according to OECD 487 guideline.
The test item did not
induce micronuclei as determined by the in vitro micronucleus
test in human lymphocytes under the experimental conditions reported.
Therefore, decan-1,2 -diol is considered to be non-mutagenic in the in
vitro micronucleus test, when tested up to cytotoxic or the highest
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