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EC number: 214-288-2
CAS number: 1119-86-4
Four groups each of four female mice were treated daily with the test
item at a concentration of 5, 10, 25 or 50% (w/v) in acetone : olive oil
4:1 (w/v) by topical application to the dorsal surface of each ear lobe
for three consecutive days. A control group of four mice was treated
with the vehicle. Five days after the first topical application, the
mice were injected intravenously with radio-labelled thymidine.
Approximately five hours after intravenous injection, the mice were
sacrificed and the draining auricular lymph nodes excised and pooled per
group. Single cell suspensions of lymph node cells were prepared from
pooled lymph nodes which were subsequently washed and incubated with
trichloroacetic acid overnight. The proliferative capacity of pooled
lymph node cells was determined by incorporation of 3H methyl thymidine
measured in a beta scintillation counter.
Disintegrations per minute were determined per lymph node sample and
Stimulation Indices (SI) relative to control group were calculated as
5% SI= 2.4
10% SI = 2.7
25% SI = 1.6
50% SI= 2.2
Calculation of the EC3 value was not possible as a SI of 3 or higher was
not reached in the study.
Decan-1,2-diol at concentrations up to 50% was found not to be a skin
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