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EC number: 214-288-2
CAS number: 1119-86-4
The study was performed to assess the irritancy potential of the test
material to the eye of the New Zealand White rabbit. The method was
designed to meet the requirements of the following: a) OECD Guidelines
for the Testing of Chemicals No. 405 "Acute Eye Irritation/Corrosion"
(adopted 24 February 1987) and b) Commission Directive 92/69/EEC Method
B5 Acute Toxicity (Eye Irritation).
A single application of the test material to the non-irrigated eye of
one rabbit produced irreversible effects. Reactions included scattered
or diffuse corneal opacity, iridial inflammation, moderate conjunctival
irritation and vascularisation of the cornea with a generalised ingrowth
of vessels for approximately 2 to 3 mm.
The test material produced irreversible ocular damage and was considered
to be a Category 1 eye irritant (irreversible effects on the eye) and
requires the Hazard Statement H318 "Causes serious eye damage".
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