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EC number: 214-288-2
CAS number: 1119-86-4
The study was performed to assess the acute dermal toxicity of the test
material in the Sprague-Dawley CD (Crl: CD® (SD) 1GS BR) strain rat. The
method was designed to meet the requirements of the following: a) OECD
Guidelines for the Testing of Chemicals No. 402 "Acute Dermal Toxicity"
(adopted 24 February 1987) and b) Commission Directive 92/69/EEC Method
B3 Acute Taxicity (Dermal).
A group of ten animals (five males and five females) was given a single,
24-hour, semi-occluded dermal application of test material to intact
skin at a dose level of 2000 mg/kg bodyweight. Clinical signs and
bodyweight development were monitored during the study. All animals were
subjected to gross necropsy.
There were no deaths. There were no signs of systemic toxicity.
In relation to the skin, very slight to well-defined erythema was noted
at the treatment sites of one male and all females. Other signs of skin
irritation noted at the treatment sites of females were a hardened light
brown coloured scab, small superficial scattered scabs, crust Formation
All animals showed expected gains in bodyweight over the study period.
No abnormalities were noted at necropsy.
The acute dermal median lethal dose (LD50) of the test material in the
Sprague-Dawley CD (Cr1: CD® (SD) IGS BR) strain rat was found to be
greater than 2000 mg/kg bodyweight.
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