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EC number: 214-288-2
CAS number: 1119-86-4
The study was performed to assess the irritancy potential of the test
material to the skin of the New Zealand White rabbit. The method was
designed to meet the requirements of the following: a) OECD Guidelines
for the Testing of Chemicals No. 404 "Acute Dermal Irritation/Corrosion-
(adopted 17 July 1992) b) Commission Directive 92/69/EEC Method B4 Acute
Toxicity (Skin Irritation). No corrosive effects were noted. However, a
single 4-hour, semi-occlusive application of the test material to the
intact skin of three rabbits produced well-defined erythema and slight
oedema. Loss of skin elasticity, crust formation and slight desquamation
were also noted.
Treated skin sites appeared normal at the 14-day observation.
Based on these data a primary irritation index of 3.2 was calculated and
this classifies the test substance as a moderate irritant to rabbit skin
according to the Draize classification scheme. However, in the three
animals tested, the test material did not demonstrate a sufficient
degree of erythema or oedema to warrant classification as a Category 2
Skin Irritant (i.e. mean values were all <2), and so is considered to be
non-irritating under CLP Regulation (EC) No. 1272/2008 (Version 4.1,
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