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EC number: 214-288-2
CAS number: 1119-86-4
The study was performed to assess the acute oral toxicity of the test
material following a single oral administration in the Sprague-Dawley CD
(Cr1: CD® ( SD) 1GS BR) strain rat. The method was designed to meet the
requirements of the following: a) OECD Guidelines for the Testing of
Chemicals No. 423 "Acute Oral Toxicity — Acute Toxic Class Method"
(adopted 22 March 1996) and b) Commission Directive 96/54/EC Method B1
tris Acute Toxicity (Oral) — Acute Toxic Class Method Method. A group of
three fasted females was treated with the test material at a dose level
of 2000 mg/kg bodyweight. This was followed by a group of three fasted
animals of the other sex at the same dose level. The test material was
administered orally as a suspension in arachis oil BP. Clinical signs
and bodyweight development were monitored during the study. All animals
were subjected to gross necropsy.
There were no deaths.
Signs of systemic toxicity noted in all males during the day of dosing
were hunched posture and lethargy. There were no signs of systemic
toxicity noted in females. All animals showed expected gains in
bodyweight over the study period and no abnormalities were noted at
The acute oral median lethal dose (LD50) of the test material in the
Sprague-Dawley CD (Crl: CD® (SD) 1GS BR) strain rat was estimated from
the flow chart Annex 3d of OECD test guideline 423 as being greater than
2500 mg/kg bodyweight.
The test material does not meet the criteria for classification for
acute toxicity according to EU CLP labelling regulations.
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