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EC number: 214-288-2
CAS number: 1119-86-4
Table 1. Summary of results
Test item concentration (μg/mL)
Proliferation index (CBPI)
Micronucleated cells (%)**
Exposure period 4 hrs without S9 mix
Exposure period 20 hrs without S9 mix
Exposure period 4 hrs with S9 mix
For the positive control groups and the test item treatment groups the
values are related to the solvent controls
The number of micronucleated cells was determined in a sample of 2000
number of micronucleated cells is statistically significantly higher
than corresponding control values
Not evaluable due to cell debris
Not determined due to strong cytotoxicity
DMSO 0.5 % (v/v) 2 MMC 1.0 μg/mL
Demecolcin 100.0 ng/mL
CPA 15.0 μg/mL
results and raw data are provided as background information.
The test item
decan-1,2-diol, dissolved in DMSO, was assessed for its potential to
induce micronuclei in human lymphocytes in vitro in the absence
and presence of metabolic activation by S9 mix, in two independent
experiments according to OECD 487 guideline.
The test item did not
induce micronuclei as determined by the in vitro micronucleus
test in human lymphocytes under the experimental conditions reported.
Therefore, decan-1,2 -diol is considered to be non-mutagenic in the in
vitro micronucleus test, when tested up to cytotoxic or the highest
The test item decan-1,2-diol, dissolved in DMSO, was assessed for its
potential to induce micronuclei in human lymphocytes in vitro in
two independent experiments according to OECD 487 guideline. The test
item did not induce micronuclei as determined by the in vitro
micronucleus test in human lymphocytes under the experimental conditions
reported. Therefore, decan-1,2 -diol is considered to be non-mutagenic
in the in vitro micronucleus test.
Decan-1,2-diol did not show any evidence of genotoxicity in Salmonella
typhimurium strains TA 1535, TA 1537, TA 98 TA 100 and TA 102, in the
presence and absence of a metabolising system. Furthermore, the test
item did not induce gene mutations at the HPRT locus in V79 cells, in
the presence and absence of a metabolising system.
Therefore, the test item is considered to be non-mutagenic.
Negative results were produced in an in vitro cytogenicity study in
mammalian cells, in a gene mutation study in mammalian cells and also in
a gene mutation study in bacterial cells. Therefore, no classification
is required for decan-1,2 -diol for this endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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