Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1993
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only an summary table was available for review.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1993

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
To investigate the acute toxicity of hexamethyldisilazane via the intraperitoneal route.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): hexamethyldisilazane

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Doses:
100-1600 mg/kg bw
No. of animals per sex per dose:
10 (total)
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
800 mg/kg bw

Any other information on results incl. tables

Time of death: 2.5 hr to 3 days
Weight change over 2 weeks: 7+
Clinical signs: Moderately weak; prostration; tremor; twitching; rough  coat; not mating.

Applicant's summary and conclusion

Conclusions:
In a tabulated summary of an acute intraperitoneal toxicity study (reliability score 4) the LD50 for hexamethyldisilazane was 800 mg/kg bw.
Executive summary:

In a tabulated summary of an acute intraperitoneal toxicity study (reliability score 4) the LD50 for hexamethyldisilazane was 800 mg/kg bw. Time to death was 2.5 hours to three days, and clinical signs were prostration, tremor, twitching, rough coat and 'not mating'.