Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
213-668-5
CAS no.:
999-97-3
Index number:
Molecular formula:
C6H19NSi2
SMILES:
C[Si](C)(C)N[Si](C)(C)C
InChI:
InChI=1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
19
Of which contain:
3 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the classification provided by companies to ECHA in REACH registrations this substance is toxic in contact with skin, is toxic if inhaled, is a highly flammable liquid and vapour, is harmful if swallowed, is harmful to aquatic life with long lasting effects, causes serious eye irritation, may cause damage to organs through prolonged or repeated exposure and causes skin irritation.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance causes severe skin burns and eye damage and is harmful if inhaled.

Breakdown of all 678 C&L notifications submitted to ECHA

Acute Tox. 4 H302
Acute Tox. 4 H332
Acute Tox. 3 H311
Flam. Liq. 2 H225
Aquatic Chronic 3 H412
Skin Corr. 1B H314
Skin Irrit. 2 H315
Eye Irrit. 2 H319
Not Classified
Acute Tox. 4 H312
Acute Tox. 3 H331
Eye Dam. 1 H318
STOT SE 3 H335
STOT RE 2 H373
Acute Tox. 3 H301
https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 34 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.

This substance is used in articles, in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles, closed processes with no likelihood of exposure and closed batch processing in synthesis or formulation.

Release to the environment of this substance can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal) and of articles where the substances are not intended to be released and where the conditions of use do not promote release. Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance can be found in complex articles, with no release intended: vehicles.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

This substance is used in the following products: semiconductors, coating products, non-metal-surface treatment products, polymers and washing & cleaning products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, mixing in open batch processes, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers and manual maintenance (cleaning and repair) of machinery.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and formulation in materials.

This substance is used in the following products: non-metal-surface treatment products, laboratory chemicals, semiconductors, pH regulators and water treatment products and coating products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: scientific research and development. This substance is used for the manufacture of: chemicals, plastic products, rubber products, electrical, electronic and optical equipment and mineral products (e.g. plasters, cement).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure and closed batch processing in synthesis or formulation.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid and as processing aid.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: keep away from heat, sparks, open flames and/or hot surfaces – No smoking; avoid release to the environment; keep container tightly closed; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. Immediately call a poison center or doctor/physician. In case of fire: Use (measures specified by manufacturer/supplier) for extinction. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.

Storage statements

Store this substance in a well-ventilated place and Keeping it cool.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • B-Lands Consulting (811689-3), OR of Hubei Bluesky New Materials Inc. 5 Place Robert Schuman - BP 1516 38025 Grenoble France France
  • BRB International B.V., Europastraat 5 6014 CD Ittervoort Netherlands
  • Cabot Performance Materials Belgium SPRL, rue Prévochamps, 78 4860 Pepinster Belgium
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED(ZHEJIANG HUTU PHARMCHEM CO., LTD.), Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chemische Fabrik Karl Bucher GmbH, An der Guenz 1 89367 Waldstetten Germany
  • Chemservice S.A - (C3H9), 13, Fausermillen 6689 Mertert Luxembourg
  • CHT Germany GmbH, Bismarckstr. 102 72072 Tuebingen Germany
  • CMC Materials Italia S.r.l. (OR), Via Umbria 4 20098 San Giuliano Milanese Milano Italy
  • Dow Silicones Belgium SPRL, Rue Jules Bordet Zone industrielle C 7180 Seneffe Belgium
  • Dow Silicones Belgium SPRL OR-1, rue Jules Bordet Parc industriel C 7180 Seneffe Belgium
  • Dow Silicones Belgium SPRL OR-2, Rue Jules Bordet Parc industriel C 7180 Seneffe Belgium
  • ELKEM SILICONES FRANCE S.A.S., Immeuble DANICA 21, Avenue Georges Pompidou 69003 Lyon France
  • ELKEM SILICONES FRANCE SAS (OR - Elkem Silicones USA Corp.), Immeuble DANICA 21, Avenue Georges Pompidou 69003 LYON France
  • ELKEM SILICONES FRANCE SAS (OR BNCM Co. Ltd), Immeuble Danica 21, Avenue Georges Pompidou 69003 LYON France
  • EUROAPI FRANCE, 15 rue Traversière 75012 Paris France
  • Evonik Operations GmbH, Rellinghauser Straße 1-11 45128 Essen Germany
  • Evonik Operations GmbH - Si 03, Rellinghauser Straße 1 - 11 45128 Essen Germany
  • FUJIFILM Electronic Materials (Europe) N.V., Keetberglaan 1A Haven 1061 2070 Zwijndrecht Antwerp Belgium
  • knoell Germany - OR - B23, Konrad-Zuse-Ring 25 68163 Mannheim Germany
  • Labcorp Development SA 023, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 - 5 Planta 28050 Madrid Spain
  • Labcorp Development SA 151, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain
  • Lanya Chemical Europe GmbH, Lütticher Straße 132 40547 Düsseldorf Germany
  • Momentive Performance Materials GmbH, Chempark, Building V7 PO 4502311119 51368 Leverkusen NRW Germany
  • NuSil Technology LLC, 1198 Avenue Maurice Donat 06 906 06250 Mougins France
  • OLON Spa, Strada Rivoltana Km 6/7 20053 RODANO Milano Italy
  • PHARMEGIC HEALTHCARE LIMITED, 6th Floor, Konstitucijos av. 21A, 08130 Vilnius Lithuania Ireland
  • Shin-Etsu Silicones Europe BV, Bolderweg 32 1332 AV Almere Netherlands
  • Shin-Etsu Silicones Europe BV - ORT, Bolderweg 32 1332 AV Almere Netherlands
  • Specialty Electronic Materials Belgium SRL OR-1, Boulevard d’Angleterre 2 1420 Braine-l’Alleud Belgium
  • UNION QUIMICO FARMACÉUTICA S.A., Mallorca 262 08008 Barcelona Barcelona Spain
  • Wacker Chemie AG, Hanns-Seidel-Platz 4 81737 Muenchen Germany
  • Wacker Chemie AG (OR_WCC), Johannes-Hess-Strasse 24 84489 Burghausen Germany

Substance names and other identifiers

1,1,1,3,3,3-hexamethyldisilazane
EC Inventory, Substance Evaluation - CoRAP, REACH pre-registration
1,1,1,3,3,3-Hexamethyldisilazane
Substance Evaluation - CoRAP, REACH pre-registration, Other
1,1,1-Trimethyl-N-(trimethylsilyl)silanamine
Other
Bis(trimethylsilyl)amine
Other
Disilazane, 1,1,1,3,3,3-hexamethyl-
Other
Hexamethyldisilazane
Other
Hexamethylsilazane
Other
HMDS
Other
OAP
Other
Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-
Other
SZ 6079
Other
Tri-Sil
Other
TSL 8802
Other
1,1,1,3,3,3-Hexamethyldisilazan
C&L Inventory
1,1,1,3,3,3-Hexamethyldisilazane
C&L Inventory, Registration dossier
1,1,1,3,3,3-hexamethyldisilazane
C&L Inventory, Registration dossier
1,1,1,3,3,3-Hexamethyldisilazane 
C&L Inventory
1,1,1-Trimethyl-N-(trimethylsilyl)silanamine
C&L Inventory, Registration dossier
[dimethyl-(trimethylsilylamino) silyl]methane
C&L Inventory
[dimethyl-(trimethylsilylamino)silyl]methane
C&L Inventory, Registration dossier, Other
bis(trimethylsilyl)amine
C&L Inventory, Registration dossier, Other
Bis(trimethylsilyl)amine
C&L Inventory, Registration dossier, Other
dimethyl-(trimethylsilylamino)silyl]...
C&L Inventory
hexaalkyldisilazane
Registration dossier
hexaalkylsilazane
Registration dossier
HEXAMETHYLDISILAZANE
C&L Inventory, Registration dossier
Hexamethyldisilazane
C&L Inventory, Registration dossier
HMDS
Registration dossier
Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-
C&L Inventory
Trimethyl-N-(trimethylsilyl)silanamine
C&L Inventory
Trimethyl-N-(trimethylsilyl)silanamine
Registration dossier
1,1,1,3,3,3-Hexamethyldisilazan
Registration dossier
A-166
Registration dossier
Dow Corning(R) 4-2839 INT (PL fluid)
Registration dossier
Dow Corning(R) Z-6079 silazane
Registration dossier
Dynasylan(R) HMDS
Registration dossier
Hexamethyldisilazane
Registration dossier
SC3100Z
Registration dossier
SH4002ZNC911
Registration dossier
SH8270U
Registration dossier
SH9151U
Registration dossier
SH9161U
Registration dossier
SL2501A
Registration dossier
SL3358A
Registration dossier
SL3358B
Registration dossier
SL7230A
Registration dossier
SL7230B
Registration dossier
SL7240A
Registration dossier
SL7240B
Registration dossier
SL7250ATT903
Registration dossier
SL7250ATT905
Registration dossier
SL7250BTT903
Registration dossier
SL7250BTT905
Registration dossier
SL7260A
Registration dossier
SL7260ATT903
Registration dossier
SL7260ATT907
Registration dossier
SL7260B
Registration dossier
SL7260BTT903
Registration dossier
SL7260BTT907
Registration dossier
SL7270A
Registration dossier
SL7270ATT903
Registration dossier
SL7270B
Registration dossier
SL7270BTT903
Registration dossier
SL8601ACG791
Registration dossier
SL8601ACG792
Registration dossier
SL8601BCG791
Registration dossier
SL8601BCG792
Registration dossier
SL8609A
Registration dossier
SL8609ACG792
Registration dossier
SL8609B
Registration dossier
SL8609BCG792
Registration dossier
SL8640A
Registration dossier
SL8640B
Registration dossier
SL9051A
Registration dossier
SL9051B
Registration dossier
SL9055A
Registration dossier
SL9055B
Registration dossier
SL9340A
Registration dossier
SL9340B
Registration dossier
SL9805ARM102
Registration dossier
SM8110Z
Registration dossier
SM8120Z
Registration dossier
103737-28-6
CAS number
Other
116638-29-0
CAS number
Other
127290-38-4
CAS number
Other
18186-75-9
CAS number
Other
761458-30-4
CAS number
Other
999-97-3
CAS number
EC Inventory, C&L Inventory, Substance Evaluation - CoRAP, Registration dossier, REACH pre-registration, Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 3 studies submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [1]
C Form
Liquid (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)
Form
Liquid (100%)
Colour
colourless (100%)

Melting/freezing point

Study results
  • 5 studies submitted
  • 1 study processed
R Melting / freezing point
-76.2 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
-76.2 °C

Boiling point

Study results
  • 9 studies submitted
  • 1 study processed
R Boiling point
125 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 7
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
125 °C

Density

Study results
  • 8 studies submitted
  • 1 study processed
R Relative density
0.774 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 5
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
0.774

Vapour pressure

Study results
  • 9 studies submitted
  • 1 study processed
R Vapour pressure
19 - 74 hPa @ 20 - 50 °C [3]

Type of Study provided
Studies with data
Key study 1
Supporting study 2 5
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Vapour pressure
19 - 8 611 hPa @ 20 - 25 °C

Partition coefficient

Study results
  • 4 studies submitted
  • 1 study processed
R Pow
15.4 @ 25 °C and pH 7.1 [1]
R Log Pow
1.19 @ 25 °C and pH 7.1 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
0.23 - 1.19 @ 20 - 25 °C

Water solubility

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 3 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Water solubility
995 - 510 000 mg/L @ 20 - 24 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 10 studies submitted
  • 1 study processed
R Flash point
11.4 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3 5
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
11.4 °C

Auto flammability

Study results
  • 8 studies submitted
  • 1 study processed
R Autoflammability / self-ignition
331 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3 3
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
331 °C

Flammability

Study results
  • 7 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2 1
Weight of evidence
Other 1
Data waiving
Not feasible 1
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Flammable (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
Non oxidising (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 2 studies submitted
  • 1 study processed
R kinematic viscosity (in mm²/s)
0.9 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Static viscosity at 20 °C
0.9 mm²/s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 3
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Half life in air
4.1 - 18 days
Degradation rate constant with OH radicals
0 - 0 cm³ molecule-1 d-1

Hydrolysis

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 1 study submitted
  • 1 study processed
C Interpretation of results
Not readily biodegradable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)
Type of water
Freshwater (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Koc at 20°C
13 - 43.5

Henrys law constant (H)

Study results
  • 1 study submitted
  • 1 study processed
R H - dimensionless
-2.77 @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Henry's law constant
4.2 - 17 Pa.m³.mol-1 @ 12 - 25 °C

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 3 summaries submitted
  • 3 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 120 - 265 µg/L (2)
Intermittent releases (freshwater) 1.2 - 2 mg/L (2)
Marine water 2.8 - 12 µg/L (2)
Intermittent releases (marine water) No hazard identified (1)
Sewage treatment plant (STP) 5 - 66.7 mg/L (2)
Sediment (freshwater) 970 µg/kg sediment dw (1)
Sediment (marine water) 97 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (3)
Hazard for Terrestrial Organism
Soil 120 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning 27 mg/kg food (1)

Short–term toxicity to fish

Study results
  • 5 studies submitted
  • 3 studies processed
P/RResults
LC50 (4 days) 83 - 271 000 µg/L [3]
LC50 (72 h) 476 mg/L [1]
LC50 (48 h) 523 mg/L [1]
LC50 (24 h) 949 mg/L [1]
LC0 (4 days) 128 mg/L [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
NOEC (73 days) 14 µg/L [1]
LOEC (73 days) 22 - 27 µg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 4 studies submitted
  • 2 studies processed
P/RResults
EC50 (48 h) 80 - 124 mg/L [2]
EC50 (24 h) 905 mg/L [1]
EC100 (48 h) 144 mg/L [1]
NOEC (48 h) 25 - 60 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
EC50 (4 days) 625 - 1 053 mg/L [3]
EC50 (72 h) 19 - 1 053 mg/L [7]
NOEC (4 days) 70 - 522 mg/L [3]
NOEC (72 h) 2.7 - 70 mg/L [7]
EC10 (72 h) 2.7 - 7.5 mg/L [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
EC50 for freshwater algae
2 - 50 mg/L
EC10 or NOEC for freshwater algae
7.5 - 44 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
EC50 (3 h) 6.67 g/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
6.67 g/L

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 4 summaries submitted
  • 4 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 53 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 106 mg/m³ repeated dose toxicity
Local Effects
Long-term: (DNEL) 133 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 341 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 7.5 mg/kg bw/day repeated dose toxicity
Acute /short term: (Medium hazard (no threshold derived)) -
Local Effects
Long-term: (Low hazard (no threshold derived)) -
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 3.6 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 400 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential

Acute toxicity

Study results
oral
  • 12 studies submitted
  • 1 study processed
P/RResults
LD50 1.1 mL/kg bw (rat) [1]
M/CInterpretations of results
Category 4 based on GHS criteria [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 10
Weight of evidence
Other 1
Data waiving
no waivers
inhalation
  • 8 studies submitted
  • 1 study processed
P/RResults
LC50 (6 h) 1 516 ppm (rat) [1]
M/CInterpretations of results
Category 4 based on GHS criteria [1]

inhalation
Studies with data
Key study 1
Supporting study 6
Weight of evidence
Other 1
Data waiving
no waivers
dermal
  • 5 studies submitted
  • 1 study processed
P/RResults
LD50 544 - 585 mg/kg bw (rabbit) [2]
M/CInterpretations of results
Category 3 based on GHS criteria [1]

dermal
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other 1
Data waiving
no waivers
other routes
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 847 mg/kg bw
Inhalation route:
Adverse effect observed LC50 10 mg/L air
Dermal route:
Adverse effect observed LD50 544 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 6
Weight of evidence
Other 2 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 5
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Study data: oral
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 6 studies submitted
  • 1 study processed
P/RResults
NOAEC (rat): 400 ppm [1]

Study data: inhalation
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other 1
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Inhalation route - systemic effects:
No adverse effect observed NOAEC 2 640 mg/m³ (subchronic, rat)
Inhalation route - local effects:
No adverse effect observed NOAEC 2 640 mg/m³ (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 3
Supporting study 5 1
Weight of evidence
Other 3
Data waiving
no waivers
Study data: in vivo
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 2 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 2
Data waiving
no waivers
Study data: developmental
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1 1
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Inhalation route:
No adverse effect observed NOAEC 2 640 mg/m³ (subacute, rat)
Effect on developmental toxicity
Oral route:
Adverse effect observed NOAEL 150 mg/kg bw/day (subacute, rat)
Inhalation route:
No adverse effect observed NOAEC 2 640 mg/m³ (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant