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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
other: Letter
Adequacy of study:
supporting study
Study period:
No data
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
other:
Title:
No information
Author:
Union Carbide Corporation
Year:
1992
Bibliographic source:
Union Carbide Corporation (1992) Initial Submission: Confidential Correspondence Regarding Employee Contact with and Aquired Sensitivity to Hexamethyldisilizane with Letter Dated 09/29/92. (microfiche OTS0555769; Document No. 8EHQ-1092-12163)

Materials and methods

Type of study / information:
Case report in a letter
Endpoint addressed:
skin sensitisation
Principles of method if other than guideline:
Not a study

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Hexamethylsilazane

Method

Details on study design:
Not a study

Results and discussion

Results:
Apparent severe skin reaction.

Applicant's summary and conclusion

Conclusions:
In 1992, a 28-year old employee who had worked with HMDZ for approximately 2 12/ years, began to experience symptoms (welts on his  hands and 
arms; swelling of his face; subsequent headaches and nose  bleeds) consistent with an unusually sensitive allergic sensitization reaction to HMDZ.  
The employee was referred to a dermatologist for  evaluation and told that his skin reaction on contact with HMDZ could  "predict a potential for a 
fatal anaphylactic reaction".  No further  details are available.
Executive summary:

In 1992, a 28-year old employee who had worked with HMDZ for approximately 2 12/ years, began to experience symptoms (welts on his  hands and 

arms; swelling of his face; subsequent headaches and nose  bleeds) consistent with an unusually sensitive allergic sensitization reaction to HMDZ.  

The employee was referred to a dermatologist for  evaluation and told that his skin reaction on contact with HMDZ could  "predict a potential for a 

fatal anaphylactic reaction".  No further  details are available.